著者
西岡 雅行 福田 正博 根来 俊一 高田 実 楠 洋子 益田 典幸 瀧藤 伸英 松井 薫 中島 俊文 小野山 靖人
出版者
日本肺癌学会
雑誌
肺癌 (ISSN:03869628)
巻号頁・発行日
vol.31, no.3, pp.335-341, 1991-06-20
被引用文献数
2

切除不能の肺非小細胞癌17例に対して,シスプラチン(100mg/m^2,day1),ビンデシン(3mg/m^2,dayl and day8)と胸部放射線照射(2Gy/day,day2〜15)の同時併用療法を行った.適格例は16例で,腫瘍効果はPR/2例,NC3例,PD1例,奏効率は75%であった.骨髄抑制は強く,食道炎も高頻度に発生したが一過性で,その他に重篤な合併症はみられなかった.本療法は許容範囲内の副作用で,高い奏効率が示されたことから,IIIA,IIIB期の切除不能肺非小細胞癌に有効な治療法と考えられた.
著者
池岡 博之 大橋 淑宏 丸岡 健一 古下 博之 中井 義明 小野山 靖人
出版者
一般社団法人 日本耳鼻咽喉科学会
雑誌
日本耳鼻咽喉科学会会報 (ISSN:00306622)
巻号頁・発行日
vol.88, no.11, pp.1562-1566, 1985-11-20 (Released:2008-03-19)
参考文献数
21

In order to examine the effects of irradiation on the nasal epithelium, rabbits received 200kV hard X-ray irradiation at 3, 000 rad to their nasal septum. The nasal mucosa after the irradiation was examined with scanning and transmission electron microscopy in a time-course manner. Immediately after the irradiation, few morphological changes were observed on the nasal epithelium with scanning electron microscopy, while transmission electron microscopy disclosed some morphological changes such as vacuolation and ballooning of epithelial cells, and enlargement of intercellular space. 2 weeks after the irradiation, sporadically affected changes were observed. The affected signs of the epithelial cells were observed at the wider area according to the course of time after the irradiation. 4 weeks after the irradiation, stratified arrangement of non-ciliated cells or undifferentiated cells were noted in an extensive area of the nasal mucosa 8 weeks after the irradiation, the nasal epithelium were chiefly consisted of undifferentiated cells. Accordingly, the following conclusions were derived from the present investigation; 1) Irradiation affected the nasal ciliary epithelium. 2) The damage of the nasal epithelium by irradiation was not recovered easily.