著者
Yamasaki Chisato Murakami Katsuhiko Fujii Yasuyuki Sato Yoshiharu Harada Erimi Takeda Jun-ichi Taniya Takayuki Satake Ryuichi Kikugawa Shingo Shimada Makoto Tanino Motohiko Halligan Brian Shimoyama Mary Twigger Simon Yura Kei Kimura Kouichi Yasuda Tomohiro Nishikawa Tetsuo Akiyama Yutaka Motono Chie Mukai Yuri Shionyu Masafumi Nagasaki Hideki Suwa Makiko Horton Paul Kikuno Reiko Ohara Osamu Lancet Doron Eveno Eric Graudens Esther Imbeaud Sandrine Debily Marie Anne Jia Libin Hayashizaki Yoshihide Amid Clara Han Michael Osanger Andreas Endo Toshinori Thomas Michael A. Hirakawa Mika Makalowski Wojciech Nakao Mitsuteru Kim Nam-Soon Thierry-Mieg Danielle Yoo Hyang-Sook De Souza Sandro J. Bonaldo Maria de Fatima Niimura Yoshihito Kuryshev Vladimir Schupp Ingo Wiemann Stefan Bellgard Matthew Thierry-Mieg Jean Wagner Lukas Zhang Qinghua Go Mitiko Minoshima Shinsei Ohtsubo Masafumi Hanada Kousuke Koyanagi Kanako O. Tonellato Peter Isogai Takao Zhang Ji Lenhard Boris Kim Sangsoo Chen Zhu Hinz Ursula Estreicher Anne Nakai Kenta Makalowska Izabela Barrero Roberto A. Hide Winston Tiffin Nicola Wilming Laurens Chakraborty Ranajit Soares Marcelo Bento Chiusano Maria Luisa Suzuki Yutaka Auffray Charles Yamaguchi-Kabata Yumi Itoh Takeshi Gough Craig Hishiki Teruyoshi Fukuchi Satoshi Nishikawa Ken Sugano Sumio Nomura Nobuo Tateno Yoshio Imanishi Tadashi Gojobori Takashi Chun Hong-Woo Habara Takuya Hanaoka Hideki Hayakawa Yosuke Hilton Philip B. Kaneko Yayoi Kanno Masako Kawahara Yoshihiro Kawamura Toshiyuki Matsuya Akihiro Nagata Naoki Nishikata Kensaku Ogura Noda Akiko Nurimoto Shin Saichi Naomi Sakai Hiroaki Sanbonmatsu Ryoko Shiba Rie Suzuki Mami Takabayashi Kazuhiko Takahashi Aiko Tamura Takuro Tanaka Masayuki Tanaka Susumu Todokoro Fusano Yamaguchi Kaori Yamamoto Naoyuki Okido Toshihisa Mashima Jun Hashizume Aki Jin Lihua Lee Kyung-Bum Lin Yi-Chueh Nozaki Asami Sakai Katsunaga Tada Masahito Miyazaki Satoru Makino Takashi Ohyanagi Hajime Osato Naoki Tanaka Nobuhiko Suzuki Yoshiyuki Ikeo Kazuho Saitou Naruya Sugawara Hideaki O'Donovan Claire Kulikova Tamara Whitfield Eleanor
出版者
Oxford University Press
雑誌
Nucleic Acids Research (ISSN:03051048)
巻号頁・発行日
vol.36, no.1, pp.D793-D799, 2008-01
被引用文献数
12

Here we report the new features and improvements in our latest release of the H-Invitational Database (H-InvDB; http://www.h-invitational.jp/), a comprehensive annotation resource for human genes and transcripts. H-InvDB, originally developed as an integrated database of the human transcriptome based on extensive annotation of large sets of full-length cDNA (FLcDNA) clones, now provides annotation for 120 558 human mRNAs extracted from the International Nucleotide Sequence Databases (INSD), in addition to 54 978 human FLcDNAs, in the latest release H-InvDB_4.6. We mapped those human transcripts onto the human genome sequences (NCBI build 36.1) and determined 34 699 human gene clusters, which could define 34 057 (98.1%) protein-coding and 642 (1.9%) non-protein-coding loci; 858 (2.5%) transcribed loci overlapped with predicted pseudogenes. For all these transcripts and genes, we provide comprehensive annotation including gene structures, gene functions, alternative splicing variants, functional non-protein-coding RNAs, functional domains, predicted sub cellular localizations, metabolic pathways, predictions of protein 3D structure, mapping of SNPs and microsatellite repeat motifs, co-localization with orphan diseases, gene expression profiles, orthologous genes, protein–protein interactions (PPI) and annotation for gene families. The current H-InvDB annotation resources consist of two main views: Transcript view and Locus view and eight sub-databases: the DiseaseInfo Viewer, H-ANGEL, the Clustering Viewer, G-integra, the TOPO Viewer, Evola, the PPI view and the Gene family/group.
著者
Minli WANG Megumi HADA Janice HUFF Janice M. PLUTH Jennifer ANDERSON Peter O'NEILL Francis A. CUCINOTTA
出版者
Journal of Radiation Research Editorial Committee
雑誌
Journal of Radiation Research (ISSN:04493060)
巻号頁・発行日
vol.53, no.1, pp.51-57, 2012 (Released:2012-02-02)
参考文献数
27
被引用文献数
13

TGFβ is a key modulator of the Epithelial–Mesenchymal Transition (EMT), a process important in cancer progression and metastasis, which leads to the suppression of epithelial genes and expression of mesenchymal proteins. Ionizing radiation was found to specifically induce expression of the TGF-β1 isoform, which can modulate late post-radiation changes and increase the risk of tumor development and metastasis. Interactions between TGFβ induced EMT and DNA damage responses have not been fully elucidated, particularly at low doses and following different radiation quality exposures. Further characterization of the relationship between radiation quality, EMT and cancer development is warranted. We investigated whether space radiation induced TGFβ dependent EMT, using hTERT immortalized human esophageal epithelial cells (EPC2-hTERT) and non-transformed mink lung epithelial cells (Mv1Lu). We have observed morphologic and molecular alterations in EPC2 and Mv1Lu cells consistent with EMT after pre-treatment with TGFβ1. This effect could be efficiently inhibited in both cell lines by the use of a TGFβRI inhibitor. High-energy silicon or iron nuclei were each able to cause a mild induction of EMT, with the inclusion of TGFβ1 inducing a greatly enhanced EMT phenotype even when cells were irradiated with doses as low as 0.1 Gy. A further enhancement of EMT was achieved at a higher dose of 2 Gy. TGFβRI inhibitor was able to reverse the EMT induced by the combination of TGFβ1 and radiation. These studies indicate that heavy ions, even at a low dose, may trigger the process of TGFβ1–induced EMT, and suggest further studies are needed to determine whether the chronic exposures received in space may potentiate this process in astronauts, leading to an increased risk of cancer.
著者
Ali A. Thabet Anwar A. Ebid Mohamed E. El-Boshy Afnan O Almuwallad Elham A Hudaimoor Fatimah E Alsaeedi Rahaf H. Alsubhi Rahaf H. Almatrook Rawan F. Aljifry Saja H. Alotaibi Shuroq M. Almallawi Wejdan O. Abdulmuttalib
出版者
The Society of Physical Therapy Science
雑誌
Journal of Physical Therapy Science (ISSN:09155287)
巻号頁・発行日
vol.33, no.9, pp.695-699, 2021 (Released:2021-09-01)
参考文献数
42
被引用文献数
5

[Purpose] To determine the effect of pulsed high intensity laser therapy (HILT) versus low level laser therapy (LLLT) in the treatment of primary dysmenorrhea. [Participants and Methods] This was a randomized clinical trial that included 30 females diagnosed with primary dysmenorrhea who were assigned randomly into two groups of equal numbers. The treatment was three sessions every cycle for three consecutive cycles, where group (A) received pulsed HILT and group (B) received LLLT. All participants were evaluated before and after treatment sessions by visual analogue scale (VAS) and at the end of treatment by pain relief scale (PRS). [Results] The results showed a significant decrease in the severity of pain in the two groups. Comparison between the two groups showed a statistically non-significant difference in the severity of pain and pain alleviation at the end of the treatment course. [Conclusion] Both pulsed HILT and LLLT are effective in the treatment of primary dysmenorrhea, with no significant differences between the two modalities.
著者
D. CESANA O.J. BENEDICTOW R. BIANUCCI
出版者
The Anthropological Society of Nippon
雑誌
Anthropological Science (ISSN:09187960)
巻号頁・発行日
pp.161011, (Released:2017-03-17)
被引用文献数
11

Spread by infected galleys coming from Kaffa (Crimea), the Black Death reached Genoa, as it now seems, in the late summer of 1347 AD. Genoa functioned as an epicentre from which the contagion was spread into the mainland through a complex system of routes, which linked Liguria to northern and central Italy. Along these routes various institutions were found, namely ‘ospitali’ (hospitals) and ‘stationes’ (stations), where traders and pilgrims stopped to rest and recuperate. In 2006 a multiple burial archaeologically dated to the second half/end of the 14th century was discovered in the cemetery pertaining to the ‘ospitale’ of San Nicolao (Genoa). The excavation showed that it contained the remains of four individuals: a 38–40 week pregnant woman with her fetus and two sub-adults. Stratigraphy showed that these individuals were buried simultaneously. Given that the dating of the burial fits the arrival of the Second Pandemic in Europe, it was hypothesized that they might have died during the Black Death epidemic. The identification of Yersinia pestis F1 antigen in three of four individuals corroborated this hypothesis. Here we report the first evidence of Y. pestis infection in 14th-century Liguria and discuss the possible mechanisms of plague dissemination from Genoa into the surrounding regions. In fact, the ‘ospitale’ of San Nicolao, located at 792 m a.s.l. into the Bracco Massif, was used as a resting place/hostel by traders and travellers (e.g. pilgrims heading for Rome). This ‘ospitale’ represented a key point leading into a system of pathways forming the initial part of the Vie Romee better known under the name of Via Francigena in the Italian territory and, as a consequence, was the ideal site from which plague could be disseminated.
著者
Justus O. Omweri Keita W. Suzuki Shouji Houki Edouard Lavergne Hiroshi Inoue Hisashi Yokoyama Yoh Yamashita
出版者
The Plankton Society of Japan, The Japanese Association of Benthology
雑誌
Plankton and Benthos Research (ISSN:18808247)
巻号頁・発行日
vol.16, no.4, pp.278-291, 2021-11-17 (Released:2021-11-18)
参考文献数
64

The euryhaline mysid Neomysis awatschensis occurs widely in estuaries and brackish lakes in Japan. Although N. awatschensis may serve as an essential energy channel to higher trophic levels, its feeding ecology has been studied only in sheltered and desalinated Lake Kasumigaura. To determine major food sources for N. awatschensis, monthly sampling was conducted during the day along the microtidal Yura River estuary from March 2014 to July 2015. Additional sampling was conducted in May 2019 to assess diel vertical migration in relation to feeding. Microscopic examinations revealed that benthic diatoms (e.g. Bacillaria paxillifer and Navicula spp.) dominated in the stomach irrespective of developmental stage, diel cycle, or season. Stable carbon and nitrogen isotope ratios in N. awatschensis and its potential food sources indicated great contributions to the diet of N. awatschensis from benthic microalgae (mainly benthic diatoms) in 2014 and from particulate organic matter (mainly phytoplankton) in 2015. Although N. awatschensis always concentrated close to the bottom in 2019, diel vertical migration might have happened in 2015, when fresh water occupied the whole estuary possibly due to river mouth clogging. Under the stagnant and oligohaline conditions, N. awatschensis could have swum up into the water column and fed on phytoplankton at night in 2015. This hypothesis may resolve the apparent contradiction between the microscopy and stable isotope analysis in 2015. In the Yura River estuary, N. awatschensis feeds primarily on benthic diatoms, although it can utilize phytoplankton flexibly in response to prevailing environmental conditions.
著者
Michael O. Adu David O. Yawson Malcolm J. Bennett Martin R. Broadley Lionel X. Dupuy Philip J. White
出版者
Plant Root 編集委員会
雑誌
Plant Root (ISSN:18816754)
巻号頁・発行日
vol.11, pp.16-32, 2017 (Released:2017-05-16)
参考文献数
67
被引用文献数
7

Rhizoboxes are soil-root compartments that may well provide the closest naturalistic conditions for studying root systems architectures (RSAs) in controlled environments. Rhizobox-based studies can however lead to mis-estimation of root traits due to poor recovery of roots and loss of fine root features during washing of roots. We used a novel scanner-based rhizobox system to evaluate: (i) RSA traits of Brassica rapa genotypes; (ii) the relationship between root traits recorded from rhizoboxes and those of harvested roots and (iii) genotypic variation of seedlings in response to external P ([P]ext) availability. Brassica rapa genotypes were grown in soil-filled rhizoboxes abutting flatbed scanners and were watered once with either deionised water or a solution of 600 ΜM KH2PO4 to approximately 80% field capacity on a weight basis. Shoot and root P concentrations ([P]shoot and [P]root) of the B. rapa lines grown on different [P]ext were quantified. Visible root length at the surface of rhizoboxes constituted 85% of the total root length recovered from harvested root samples. High P supply induced a strong increase in [P]shoot in all genotypes (P < 0.001) whereas low P supply generally led to greater partitioning to roots. Seed P concentration and tissue P concentration were correlated only at low [P]ext. Total root length was strongly correlated with tissue P content under both low [P]ext (r = 0.81, P < 0.05) and high [P]ext (r = 0.82, P < 0.05) conditions. The novel scanner-based rhizobox system used addresses the substantial limitations associated with current use of rhizoboxes to study root growth dynamics.
著者
M.O
出版者
医学書院
雑誌
病院 (ISSN:03852377)
巻号頁・発行日
vol.30, no.11, pp.114-115, 1971-10-01

保険医総辞退に至るまでの経過 中医協の診療報酬体系の適正化に関する‘審議用メモ’に端を発し,7月1日から突入した日本医師会の保険医総辞退は,7月28日の佐藤総理,斎藤厚相,武見日木医師会長の三者会談でようやく収拾され,木年の2月18日以来審議を中止していた中央社会保険医療協議会が約半年ぶりの8月5日にようやく開かれ,軌道に乗ってきた. そこでこの間のおもな動きをあげてみた.
著者
Stephen A. McCullough Michael A. Fifer Pouya Mohajer Patricia A. Lowry Caitlin O’Callaghan Reen Aaron L. Baggish Gus J. Vlahakes Yuichi J. Shimada
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-17-0959, (Released:2018-03-09)
参考文献数
25
被引用文献数
8

Background:The clinical characteristics associated with elevated right atrial pressure (RAP) in hypertrophic cardiomyopathy (HCM) are unknown. Few data exist as to whether elevated RAP has prognostic implications in patients with HCM. This study investigated the clinical correlates and prognostic value of elevated RAP in HCM.Methods and Results:This retrospective cohort study was performed on 180 patients with HCM who underwent right heart catheterization between 1997 and 2014. Elevated RAP was defined as >8 mmHg. Baseline characteristics, mean pulmonary artery pressure, and mean pulmonary capillary wedge pressure (PCWP) were assessed for association with elevated RAP. The predictive value of elevated RAP for all-cause mortality and the development of atrial fibrillation (AF), ventricular tachycardia/fibrillation (VT/VF), and stroke was evaluated. Elevated RAP was associated with higher New York Heart Association class, dyspnea on exertion, orthopnea, edema, jugular venous distention, larger left atrial size, right ventricular hypertrophy, higher pulmonary artery pressure, and higher PCWP. RAP independently predicted all-cause mortality (adjusted hazard ratio [aHR] 2.18 per 5-mmHg increase, 95% confidence interval [CI] 1.05–4.50, P=0.04) and incident AF (aHR 1.85 per 5-mmHg increase, 95% CI 1.20–2.85, P=0.005). Elevated RAP did not predict VT/VF (P=0.36) or stroke (P=0.28).Conclusions:Elevated RAP in patients with HCM is associated with left-sided heart failure and is an independent predictor of all-cause mortality and new-onset AF.
著者
SONG XING YING GUAN MACKIE O’HARA HUIYANG CAI XIAOMIN WANG XING GAO
出版者
The Anthropological Society of Nippon
雑誌
Anthropological Science (ISSN:09187960)
巻号頁・発行日
pp.170802, (Released:2017-09-29)
被引用文献数
2 5

Recent fossil finds have complicated the picture of East Asian Late Pleistocene hominin taxonomy and morphology, necessitating analysis of more fossils with secure dates and stratigraphic contexts to better contextualize human evolution during this epoch. Field excavations at the Laoya Cave in Guizhou Province, China in 2013 recovered two isolated human teeth (M3 and dm2). The teeth date from ~21–24 kya, according to AMS radiocarbon dating. The present study provides detailed metric and non-metric descriptions of the Laoya teeth, and compares them with the dentition of other Late Pleistocene hominins (Neanderthals and fossil Homo sapiens from around the world) as well as chronologically earlier fossil hominins from the same geographical area (East Asian Early/Middle Pleistocene hominins). To achieve this, descriptive morphological observations, geometric morphometric analysis, and micro-computed tomography were employed. The lower third molar (LYC1) is characterized by several derived features, including the absence of a hypoconulid, the lack of C6 and C7, and an ‘X’-type cuspal arrangement. The combination of traits expressed by LYC1 is unique, but very similar to other recent H. sapiens. However, the LYC1 also displays a suite of dental features that are not common in other East Asian Late Pleistocene fossil H. sapiens: the absence of a hypoconulid, the presence of a middle trigonid crest, and a narrowed talonid relative to trigonid. This study of the Laoya teeth expands the known morphological diversity of East Asian Late Pleistocene hominin dentitions, and will contribute to a better understanding of the history of modern humans in this area.