13 0 0 0 OA 逐条憲法精義

著者
美濃部達吉 著
出版者
有斐閣
巻号頁・発行日
1927
著者
小野 紘彦 佐藤 和貴郎 中村 雅一 山村 隆
出版者
日本臨床免疫学会
雑誌
日本臨床免疫学会会誌 (ISSN:09114300)
巻号頁・発行日
vol.40, no.4, pp.306b-306b, 2017 (Released:2017-11-25)

【背景】筋痛性脳脊髄炎/慢性疲労症候群(ME/CFS)は著しい疲労に加え,認知機能障害や睡眠障害など様々な神経症状が生じる深刻な慢性疾患である.近年ノルウェーからリツキシマブによるB細胞除去療法の有効性が報告されたが,ME/CFSにおける末梢血リンパ球についての知見は乏しく,なぜB細胞除去療法が治療効果を発揮するか不明である.【目的】ME/CFS患者の末梢血中のB細胞異常を明らかにする.【方法】対象はカナダ基準およびInternational consensus criteriaを共に満たす患者40人と年齢,性別をマッチさせた健常者20人とした.末梢血から末梢血単核球細胞を分離し,B細胞受容体(BCR)レパトア解析とフローサイトメーターを用いたB細胞サブセット頻度及び機能分子発現の解析を行った.【結果】BCRレパトア解析では患者群において多様性指数であるNormalized shannon indexとクローナリティーの指数であるDE50が低い傾向があり,多様性の減少およびクローナリティーの増加がみられた.リンパ球サブセット解析では,患者群と健常者群で比較すると,B細胞では患者群においてplasmablastが低下し(p = 0.04),一部の患者でCD80の発現が亢進していた.【結論】ME/CFSの末梢血においてB細胞の異常が認められた.免疫異常とME/CFSの病態との関わりについてさらなる研究が必要である.
著者
大川 裕子
出版者
日本女子大学
雑誌
史艸 (ISSN:02883066)
巻号頁・発行日
vol.47, pp.11-29, 2006-11-25
著者
柴 裕之
出版者
白山史学会
雑誌
白山史学 (ISSN:03859460)
巻号頁・発行日
no.49, pp.17-39, 2013-05
著者
山田正賢 編
出版者
松雲堂
巻号頁・発行日
vol.下, 1899
著者
西山 久吉
出版者
Japan Poultry Science Association
雑誌
日本家禽学会誌 (ISSN:00290254)
巻号頁・発行日
vol.15, no.1, pp.1-11, 1978-01-30 (Released:2008-11-12)
参考文献数
188
著者
田村 千穂
出版者
日本マス・コミュニケーション学会
雑誌
マス・コミュニケーション研究 (ISSN:13411306)
巻号頁・発行日
vol.74, pp.115-132, 2009-01-31 (Released:2017-10-06)
参考文献数
13

In the early 1910s, when stage actresses emerged, the so-called “Katsudō-Actresses” appeared i n the cinema scene. I examine how they differed fromcontemporary film actresses and how they were received by audiences backthen. I analyzed the earliest film magazine of Katsudōshashinkai from 1909 to1912. The activities of Katsudō-Actresses were not limited to acting on screen.They also performed on stage as actors of chain-dramas, and dancers of sideshows played i n movie theaters. Katsudō-Actresses appealed to the audiencethrough both presentation and representation. Such uniqueness was sustainedby the circumstance of the early Japanese cinema.
著者
山中 浩明 瀬尾 和大 佐間野 隆憲
出版者
公益社団法人 日本地震学会
雑誌
地震 第2輯 (ISSN:00371114)
巻号頁・発行日
vol.44, no.1, pp.9-20, 1991-03-24 (Released:2010-03-11)
参考文献数
15

The seismic refraction survey was conducted in the southwestern part of the Tokyo Metropolitan area to make clear the deep sedimentary structure. Two explosions were made at Daikoku and Maioka in Yokohama city in 1988, and the resultant seismic waves were observed at 83 temporary observation sites along four surveying lines:a) Yumenoshima to Enoshima, b) Daikoku to Nagatsuta, c) Nagatsuta to Kanazawa, andd) around Takatsu.The travel time analysis for the above data and additional data from previous explosions in the area for reference has been made.The followings were our conclusions:1) The subsurface structure consists of five layers characterized by P-wave velocities of 1.8, 2.3, 2.9, 4.7 and 5.5km/s. The top layer with a P-wave velocity of 1.8km/s disappears around Enoshima. The layer with a P-wave velocity of 5.5km/s could not be confirmed for the southwestward area.2) The topography of the layer with a P-wave velocity of 4.7km/s forms a synclined structure having its maximum depth of more than 4km between the Maioka and Daikoku explosion sites. The depth to this layer becomes drastically shallower toward Enoshima.3) The step-like topography of the layer with a P-wave velocity of 5.5km/s, which has been found in the previous study, could not be confirmed, because of low S/N ratios of the observed seismograms.
著者
高橋 秀実
出版者
日本医科大学医学会
雑誌
日本医科大学医学会雑誌 (ISSN:13498975)
巻号頁・発行日
vol.13, no.3, pp.140-144, 2017-06-15 (Released:2017-07-20)
参考文献数
6
著者
髙畑 克徳 髙嶋 博
出版者
日本神経治療学会
雑誌
神経治療学 (ISSN:09168443)
巻号頁・発行日
vol.33, no.1, pp.9-18, 2016 (Released:2016-05-20)
参考文献数
19

Autoimmune encephalopathies are clinically and immunologically heterogeneous disorders. Over time, many different types of autoimmune encephalopathy have been discovered. In such clinical situations, we often recognize that patients with autoimmune encephalopathy are often misdiagnosed as exhibiting functional psychogenic movement, conversion, or somatoform disorders. We clinically analyzed 63 patients (14 males and 49 females; age range, 15–79 years) diagnosed with autoimmune encephalopathy in our hospital from 2013 to 2015. Throughout this period we diagnosed almost no conversion disorders in our department. These patients were diagnosed using the diagnostic criteria for each disease, following clinical features showing neurological symptoms of brain origin, responsiveness to immunosuppressive therapy, the existence of known pathological antibodies, and/or history of human papilloma virus (HPV) vaccination. Fourty–two patients showed motor disturbance (weakness, paresis of extremities, or slower pinching) and 35/42 (83.3%) patients showed give–way weakness, indicating disruption of continuous muscle contraction. Fourty–four patients showed sensory abnormalities such as strong pain, deep muscle pain, dysesthesia, paresthesia, or fast neurologic pain. Surprisingly, most pain was distributed in manner that was not explainable anatomically, while some patients also showed patchy, stocking–glove, or localized pain. Seventeen patients exhibited involuntary movements such as tremor entrainment, dystonia, or coarse involuntary movement. In most patients, such motor, sensory, or involuntary movements were markedly improved with immunosuppressive therapies such as prednisolone, azathioprine, or immune adsorption therapy. We observed memory loss, PNES (psychogenic non–epileptic seizure), dissociative amnesia, hyperventilation, opsoclonus, epilepsy, or autonomic symptoms amongst our patients. Although give–way weakness, anatomically unexplainable pain/abnormal sensation, and strange involuntary movements were thought to be psychogenic, the presence of one of these three symptoms was indicative of autoimmune encephalopathy. As autoimmune encephalitis exhibits diffuse involvement with the whole brain, these symptoms were entirely understandable. Except for the presence of organic disease, most patients were classified into somatoform disorders (DSM–IV, ICD–10) or functional movement disorders. Without first excluding autoimmune encephalopathy, we propose that physicians should not diagnose somatoform disorders. Since autoimmune encephalopathy patients often possess so–called psychogenic signs, it is possible that such signs might be generated by autoimmune encephalopathy instead of somatoform disorders. In conclusion, we propose that give–way weakness and anatomically unexplainable pain/abnormal sensation are key symptoms of autoimmune encephalopathy. We hope that many patients with autoimmune encephalopathy will now be identifiable using our new neurological examination and that each patient can be given an exact diagnosis and therefore be administered with the appropriate treatments.

15 0 0 0 OA 白秋小品

著者
北原白秋 著
出版者
阿蘭陀書房
巻号頁・発行日
1916