著者
松岡 絵理香 町田 浩一 菊地 正雄 マツオカ エリカ マチダ コウイチ キクチ マサオ Erika MATSUOKA Koichi MACHIDA Masao KIKUCHI
雑誌
東北薬科大学研究誌
巻号頁・発行日
no.52, pp.33-38, 2005-12

Two rare megastigmane glucosides, 3- and 9-O-β-D-glucopyranosides of (3S, 5R, 6R, 7E, 9S) -megastigman-7-ene-3, 5, 6, 9-tetrol (1 and 2), were isolated from Hypericum erectum THUNB. Their structures were established on the basis of chemical and spectral data. This is the first report of the isolation of each megastigmane derivative from Guttiferae plant.
著者
瀧澤 俊也 成田 紘一 渡邉 一弘 阿部 秀樹 加藤 正 タキザワ トシヤ ナリタ コウイチ ワタナベ カズヒロ アベ ヒデキ カトウ タダシ Toshiya TAKIZAWA Koichi NARITA Kazuhiro WATANABE Hideki ABE Tadashi KATOH
雑誌
東北薬科大学研究誌
巻号頁・発行日
vol.54, pp.33-47, 2007-12

Spiruchostatin A (1), isolated from a culture broth of Pseudomonas sp., has been shown to be a potent histone deacetylase (HDAC) inhibitor. HDAC inhibitors can suppress the growth of human tumor xenografts, this natural product, therefore, is expected to be a promising candidate for novel molecular-targeted anticancer agents. We envisioned that 1 would be synthesized through twofold macrolactam/macrolactone cyclization of the fully elaborated acyclic disulfide 2. The key segments 3 and 4, required for the preparation of the advanced key intermediate 2, were initially synthesized, and the two segments were subsequently subjected to the critical cross S-S coupling reaction to produce the desired key intermediate 11 (synthetically equivalent to 2). Upon deprotection of the N-Boc and the methyl ester groups in 11, the crucial cyclization formation was achieved using PyBOP to provide the desired macrolactam 16, a potential key precursor for 1. Further investigations concerning the transformation of 16 to the target molecule 1 were also described.
著者
八百板 康範 西谷 亜紗 菊地 正雄
出版者
東北薬科大学
雑誌
東北薬科大学研究誌 (ISSN:1345157X)
巻号頁・発行日
vol.57, pp.51-53, 2010-12

Five steroles were isolated from the sclerotium of Polyporus umbellatus FRIES (Polyporaceae) and identified as (22E)-ergosta-5,7,9(11),22-tetraen-3β-ol (1),ergosta-5,7-dien-dien-3β-ol (2), ergost-7-en-3β-ol (3),(22E)-ergosta-6,8(14),22-trien-3β-ol (4),and (22E)-ergosta-8(14),22-dien-3β-ol (5).Their structures were determined on the basis of spectral data.Compounds 1-5 have been isolated from the sclerotium of P.umbellatus for the first time.
著者
酒本 恵明 町田 浩一 菊地 正雄
出版者
東北薬科大学
雑誌
東北薬科大学研究誌 (ISSN:1345157X)
巻号頁・発行日
vol.54, pp.63-67, 2007-12

Six chemical constituents, oleoside dimethyl ester (1), 10-acetoxyoleoside dimethyl ester (2), 7-β-D-glucopyranosyl 11-methyl oleoside (3), lariciresinol 4'-O-β-D-glucopyranoside (4), lariciresinol 4-O-β-D-glucopyranoside (5) and conicaoside (6) were isolated from the leaves of Osmanthus ilicifolius THUNB. Their structures were established on the basis of chemical and spectral data.