文献一覧: 公益社団法人日本薬剤学会 (出版者)

285 0 0 0 OA 生薬粉末製剤の流動特性評価ならびに薬匙設計のための評価法―鎮咳去痰薬生薬製剤における取り組み―

著者: 竹内淑子中坪拓也福居篤子藤井隆太田原耕平竹内洋文
出版者: 公益社団法人日本薬剤学会
雑誌: 薬剤学 (ISSN:03727629)
巻号頁・発行日: vol.77, no.3, pp.164-176, 2017-04-01 (Released:2017-05-01)
参考文献数: 19

Flowability is one of the most important parameters of pharmaceutical powders during the handling and preparation of solid dosage forms. It is especially important to characterize the very poor flowability that some herbal powders show. In this study, the flowability of a traditional herbal powder formulated as an antitussive and expectorant was examined. This formulated herbal powder and two excipient powders, precipitated calcium carbonate and anhydrous dibasic calcium phosphate, were evaluated using two instruments. A shearing test, a wall friction test and a dynamic flowability test were performed with Powder Rheometer FT4 (Freeman Technology, Tewkesbury, UK). Internal friction and wall friction were measured. BFE (basic flow energy), SI (stability index) and FRI (flow rate index) were also measured. Angle of repose, bulk density, tapped density, angle of spatula and cohesiveness were measured with a Powder Tester (Hosokawa Micron, Osaka, Japan). The results were used to calculate Carr's Index values and compressibility, which in turn revealed that this herbal powder had poor flowability.The other aim of this study was to develop a new method of evaluating the flowability of powder through a medicine spoon. Two evaluation methods, the spoon-tap test and the consecutive medicine spoon test, were developed to design a new medicine spoon for the herbal powder. The results of these tests indicated that a polyethylene medicine spoon with holes at the bottom could reduce the adhesiveness to a medicine spoon of the formulated herbal powder.

2023-12-08 13:11:07
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38 0 0 0 OA 各種市販ミノキシジル製剤の安全性・有効性に及ぼす容器の種類の影響

著者: 藤堂浩明齋藤美幸鈴木宏宙井上裕高山幸三杉林堅次
出版者: 公益社団法人日本薬剤学会
雑誌: 薬剤学 (ISSN:03727629)
巻号頁・発行日: vol.81, no.1, pp.111-120, 2021 (Released:2021-01-01)
参考文献数: 6

It is important when developing effective and safe pharmaceutical products to select adequate active components and formulations as well as to design their containers and devices. Minoxidil was developed as a direct over-the-counter (OTC) drug in 1999 and has long been marketed only by one original company. Recently, many generic products have been marketed. However, the shape and type of the containers for these generic products differ from that of the original product, leading to a possibility that the amount of minoxidil applied by patients may differ. In the present study, the original and three typical generic products with 5% minoxidil external formulations were evaluated for their filling amounts, single application amounts, extent of distribution on application, ability to reach the scalp, and dripping properties. As a result, statistically significant differences were found in the filling amounts and ability to reach to the scalp between the products due to differences in the nozzle shape of the container. In addition, a large variation was observed in some of the generic products in terms of the drug liberation. These results indicate that it is important to suitably design and adequately evaluate the container for OTC products such as minoxidil formulations, which can exhibit toxicity from overuse, and that are easily purchased by consumers.