著者

Takashi Nagai Shunji Yachi Keiya Inao

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.47, no.1, pp.22-29, 2022-02-20 (Released:2022-02-20)

参考文献数

32

被引用文献数

1

---

We quantitatively evaluated the cumulative ecological risks from multiple pesticides used in paddy fields in Japan. Moreover, we visualized the temporal and regional variability of those risks for 1990–2010. Considering the region-specific parameters of environmental conditions, region-specific predicted environmental concentrations were estimated at 350 river-flow monitoring sites in Japan. Then the multi-substance potentially affected fraction (msPAF) was calculated as a risk index of multiple pesticides by using the computation tool NIAES-CERAP. The median msPAF values for insecticides and herbicides decreased by 92.4% and 53.1%, respectively, from 1990 to 2010. This substantial reduction in ecological risk was attributed to the development of low-risk pesticides by manufacturers, the efforts of farmers in risk reduction, and tighter regulation by the Japanese government. In particular, the substantial reduction of the ecological risk from insecticides was largely due to the decrease in the use of organophosphorus insecticides.

著者

Ray Nishimoto

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

pp.D19-101, (Released:2019-08-03)

参考文献数

16

被引用文献数

28 54

著者

Atsushi Nagamatsu Ken Ueda Ryuji Tamai Shinki Tani Shunsuke Yamamoto

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.47, no.3, pp.139-145, 2022-08-20 (Released:2022-08-20)

参考文献数

19

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Fenquinotrione is a novel rice herbicide that was discovered and developed by Kumiai Chemical Industry Co., Ltd. It can control a wide range of broadleaf and sedge weeds with excellent rice selectivity at 30 g a.i./10 a and is as effective as the wild type on acetolactate synthase inhibitor-resistant weeds. Our metabolic and molecular biological studies showed that CYP81A6-mediated demethylation and subsequent glucose conjugation are responsible for the safety of fenquinotrione in rice. Fenquinotrione was registered in Japan in 2018, and various products containing fenquinotrione have been launched. With its high efficacy and excellent rice selectivity, we believe that fenquinotrione will contribute to efficient food production in the future.

著者

Shunsuke Yamamoto Yoshitaka Tanetani Chihiro Uchiyama Atsushi Nagamatsu Masami Kobayashi Mitsumasa Ikeda Kiyoshi Kawai

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.46, no.3, pp.249-257, 2021-08-20 (Released:2021-08-31)

参考文献数

18

被引用文献数

7

---

Fenquinotrione is a novel herbicide that can control a wide range of broadleaf and sedge weeds with excellent rice selectivity. We revealed that fenquinotrione potently inhibited the 4-hydroxyphenylpyruvate dioxygenase (HPPD) activity in Arabidopsis thaliana with an IC50 of 44.7 nM. The docking study suggested that the 1,3-diketone moiety of fenquinotrione formed a bidentate interaction with Fe(II) at the active site. Furthermore, π–π stacking interactions occurred between the oxoquinoxaline ring and the conserved Phe409 and Phe452 rings, indicating that fenquinotrione competes with the substrate, similar to existing HPPD inhibitors. A more than 16-fold difference in the herbicidal activity of fenquinotrione in rice and the sedge, Schoenoplectus juncoides, was observed. However, fenquinotrione showed high inhibitory activity against rice HPPD. Comparative metabolism study suggested that the potent demethylating metabolism followed by glucose conjugation in rice was responsible for the selectivity of fenquinotrione.

著者

Masamitsu Tsukamoto Hiroshi Kikugawa Souichiro Nagayama Taketo Suganuma Tatsuya Okita Hidenori Miyamoto

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.46, no.2, pp.152-159, 2021-05-20 (Released:2021-05-25)

参考文献数

21

被引用文献数

7

---

Tolpyralate, a new selective postemergence herbicide developed for the weed control in corn, possesses a unique chemical structure with a 1-alkoxyethyl methyl carbonate group on the N-ethyl pyrazole moiety. This compound shows high herbicidal activity against many weed species, including glyphosate-resistant Amaranthus tuberculatus. Tolpyralate targets 4-hydroxyphenylpyruvate dioxygenase (4-HPPD), which is involved in the tyrosine degradation pathway. Inhibition of the enzyme destroys the chlorophyll, thereby killing the susceptible weeds. Details of tolpyralate discovery, structure optimization, and biological activities are described.

著者

Atsushi Okazawa Hiroaki Samejima Shigeru Kitani Yukihiro Sugimoto Daisaku Ohta

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

pp.D21-014, (Released:2021-05-20)

参考文献数

45

被引用文献数

8

---

Damage caused by Orobanchaceae root parasitic weeds is a substantial agricultural problem for global food security. Many studies have been conducted to establish practical methods of control, but efforts are still required for successful management. Seed germination of root parasitic weeds requires host-derived germination stimulants including strigolactones (SLs). Studies on SLs have revealed that a butenolide ring is the essential moiety for SL activity as a germination stimulant. Interestingly, recent studies have revealed that butenolide hormones regulate the biosynthesis of secondary metabolites and mediate communication in actinomycete bacteria. Because of the structural similarity between SLs and the bacterial butenolides, we evaluated the germination stimulatory activity of butenolides isolated from Streptomyces albus J1074 on root parasitic weeds. These butenolides were found to specifically induce seed germination of Orobanche minor. Our findings contribute to understanding the molecular mechanisms of germination stimulant perception and to the development of a method for their biological control.

著者

Naoki Okamoto Naoki Yamanaka

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.46, no.1, pp.23-28, 2021-02-20 (Released:2021-02-26)

参考文献数

54

被引用文献数

6

---

Ecdysteroids are a class of steroid hormones in arthropods that control molting and metamorphosis through interaction with intracellular nuclear receptors. In contrast to the extensive literature describing their biosynthetic pathways and signaling components, little has been known about how these hormones are traveling into and out of the cells through lipid bilayers of the cell membranes. Recently, a series of studies conducted in the fruit fly Drosophila melanogaster revealed that membrane transporters have critical functions in trafficking ecdysteroids across cell membranes, challenging the classical simple diffusion model of steroid hormone transport. Here we summarize recent advances in our understanding of membrane transporters involved in ecdysteroid signaling in Drosophila, with particular focus on Ecdysone Importer (EcI) that is involved in ecdysteroid uptake in peripheral tissues. We then discuss the potential advantage of EcI blockers as a novel pest management tool as compared to classical insect growth regulators.

著者

Noriharu Umetsu Yuichi Shirai

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.45, no.2, pp.54-74, 2020-05-20 (Released:2020-05-20)

参考文献数

114

被引用文献数

8 205

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General trends and strategies for novel pesticides are summarized. Global pesticide sales and pesticide discovery research are also briefly reviewed. At least 105 chemical pesticides have been launched during the past decade or are under development: 43 fungicides, 34 insecticides/acaricides, 6 nematicides, 21 herbicides, and 1 herbicide safener. Most of them are safe to humans and environmentally friendly. The most developed fungicides are SDHI (succinate dehydrogenase inhibitors), DMI (demethylation inhibitors), QoI (quinone outside inhibitors), and QiI (quinone inside inhibitors). Due to the development of resistance to fungicides with existing modes of action, many fungicides possessing various novel modes of action have been launched or are under development. The trend of insecticide development is changing from organophosphorus, carbamate, and synthetic pyrethroids to nicotinic and diamide insecticides. During the past decade, compounds possessing a variety of novel modes of action have also been launched or are under development. Flupyradifurone and flupyrimin, exhibiting extremely low honeybee toxicity, have been developed and subjected to practical use. Herbicides possessing varied modes of action, such as acetolactate synthase, p-hydroxyphenylpyruvate dioxygenase, protoporphyrinogen oxidase, and very-long-chain fatty acid elongase inhibition, have been developed, but no herbicides possessing a novel mode action have commercialized in nearly 30 years. It is of interest that cyclopyrimorate, which was recently launched, and tetflupyrolimet, which is under development, have novel modes action: homogentisate solanesyltransferase (HST) and dihydroorotate dehydrogenase (DHODH) inhibition, respectively. The development of useful acaricides and nematicides is also progressing. Some natural product origin pesticides are getting attention.

著者

Hirosato Takikawa Shigefumi Kuwahara

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

pp.D22-062, (Released:2022-12-22)

参考文献数

52

---

It was the late Professor Kenji Mori, the giant of pheromone synthesis and pioneer of pheromone stereochemistry, who laid the foundation for the practical application of insect pheromones, which play an important role in Integrated Pest Management, one of the key concepts of agriculture in the 21st century. Therefore, it would be meaningful to retrace his achievements at this time, three and a half years after his death. In this review, we would like to introduce some of his notable synthetic studies from his Pheromone Synthesis Series and reconfirm his contributions to the development of pheromone chemistry and their impacts on natural science.

著者

脇田 健夫 安井 直子 山田 英一 岸 大輔

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.30, no.2, pp.133-138, 2005-05-20 (Released:2014-06-08)

参考文献数

18

被引用文献数

10 11

著者

Daisuke Hagiwara

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

pp.D20-017, (Released:2020-05-21)

参考文献数

8

被引用文献数

20

---

Increasing numbers of azole-resistant Aspergillus fumigatus (ARAf) in the environment have become a global public health issue. We surveyed tulip bulbs that were imported from the Netherlands and found that 6.3–15.8% of bulbs were contaminated by ARAf with a tandem-repeat mutation in the promoter region of the cyp51A gene. We also showed that fungicide treatment of the tulip bulbs by benomyl or prochloraz effectively reduced the rate of isolation. This is the first report demonstrating a method of eliminating human fungal pathogens from plant bulbs.

著者

Atsushi Ishihara Kana Ando Anna Yoshioka Koichi Murata Yu Kokubo Noriko Morimoto Naoki Ube Yukinori Yabuta Makoto Ueno Shin-ichi Tebayashi Kotomi Ueno Kumiko Osaki-Oka

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.44, no.2, pp.89-96, 2019-05-20 (Released:2019-05-20)

参考文献数

36

被引用文献数

10

---

We investigated the effect of treatment with hot water extracts from the spent mushroom substrates (SMSs) of Lentinula edodes and Hypsizygus marmoreus on the resistance of rice leaves to Pyricularia oryzae infection. The spraying of the SMS extracts clearly suppressed the development of lesions caused by Py. oryzae infection. The accumulation of phytoalexins momilactones A and B, oryzalexin A, and sakuranetin was markedly induced by the spraying of extracts. The enhanced expression of defense related genes PR1b and PBZ was also found in leaves sprayed with the extracts. Treatments with the extracts also affected phytohormone levels. The levels of N6-(Δ2-isopentenyl)adenine and trans-zeatin markedly increased in response to treatment, whereas the levels of salicylic and jasmonic acids were largely unchanged.

著者

志野 真実子 濱田 崇宏 重松 由夫 平瀬 寒月 番場 伸一

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.43, no.4, pp.233-239, 2018-11-20 (Released:2018-11-20)

参考文献数

29

被引用文献数

32

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新規水稲用除草剤シクロピリモレートの作用機構を解析した.シロイヌナズナをシクロピリモレートで処理すると白化症状が見られ,プラストキノンの減少に伴ってホモゲンチジン酸が顕著に蓄積した.また,植物中で代謝物のデスモルフォリノカルボニルシクロピリモレート(DMC)が検出された.このことから,シクロピリモレートまたはDMCが,プラストキノン生合成経路で4-ヒドロキシフェニルピルビン酸ジオキシゲナーゼの下流で働くホモゲンチジン酸ソラネシルトランスフェラーゼ(HST)活性を阻害すると予想された.そこで,シロイヌナズナのHSTを用いてin vitro試験を行ったところ,シクロピリモレートは弱いHST阻害活性を,DMCは強いHST阻害活性を有していることが明らかとなった.さらに,DMC類縁体のHST阻害活性と白化活性には正の相関が認められた.以上の結果は,シクロピリモレートおよびDMCの作用点はHSTであり,本剤は商用利用される除草剤における新規作用機作をもつことを示している.

著者

Kazuharu Arakawa Masaru Tomita

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.31, no.3, pp.282-288, 2006 (Released:2006-08-24)

参考文献数

52

被引用文献数

14 28

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The advent of high-throughput measurement technologies has resulted in the rapid accumulation of “omics” information including genome, transcriptome, proteome, and metabolome data. This increase in data acquisition has lead to a demand for an efficient computational platform for in silico analysis. The G-language software suite provides a comprehensive workbench for large-scale omics research and systems biology. The suite includes a bioinformatics research framework G-language Genome Analysis Environment, which contains a Gene Prediction Accuracy Classification benchmarking tool for the quantification of the sensitivity of genome informatics analysis methods to genome annotation completeness. Omics data processed in this environment can be visualized with KEGG-based pathway mapping web service, and Genome-based Modeling System enables automatic prototyping of metabolic pathway models from the genome. The software suite covers various domains of omics, with the goal of integrating all of these data for research into systems biology.

著者

Toshiyuki Katagi Takuo Fujisawa

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

pp.D21-028, (Released:2021-09-08)

参考文献数

160

被引用文献数

7

---

The median lethal dose of pesticide in acute oral toxicity, used as a conservative index in avian risk assessment, varies by the species with differences of less than one order of magnitude, depending on body size, feeding habit, and metabolic enzyme activity. The profiles of pesticide metabolism in birds with characteristic conjugations are basically common to those in mammals, but less information is available on their relevant enzymes. The higher toxicity of some pesticides in birds than in mammals is due to the lower activity of avian metabolic enzymes. The bioaccumulation in birds is limited for very hydrophobic pesticides resistant to metabolic degradation. Several in silico approaches using the descriptors of a pesticide molecule have recently been employed to estimate the profiles of acute oral toxicity and bioaccumulation.

著者

Soichiro Ikuta Eiichiro Fukusaki Shuichi Shimma

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

pp.D22-063, (Released:2023-03-23)

参考文献数

23

---

Fungicides must penetrate the internal tissues of plants to kill pathogenic fungi. Mass spectrometers have been used to confirm this penetration, but conventional mass spectrometric methods cannot distinguish the fungicides in different internal tissues owing to the extraction steps. However, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) can detect the penetration of fungicides into leaf sections through direct analysis of the sample surfaces. Therefore, the objective of this study was to establish a method for visualizing fungicide penetration in wheat leaf cross sections using MALDI-MSI. The penetration of azoxystrobin from the epidermal to the internal tissue of the leaves was observed. Moreover, azoxystrobin accumulates in the cells around the vascular bundle. This study suggests that MSI can be useful for the evaluation of fungicide penetration in plant leaves.

著者

Ikuo Takahashi Hikaru Koishihara Tadao Asami

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

pp.D22-022, (Released:2022-09-14)

参考文献数

38

被引用文献数

1

---

The inhibitory effect of propiconazole on strigolactone (SL) production and Striga hermonthica emergence were evaluated using rice plants. A significant reduction in SL levels was detected in root and root exudates after rice was treated with different doses of propiconazole. Propiconazole induced second tiller bud outgrowth in rice seedlings. In accordance with the results of 4-deoxyorobanchol levels in root and root exudates, propiconazole-treated rice attenuated the degree of infestation of the root parasitic weed, S. hermonthica. Overall, these results suggest that propiconazole has potential as a plant growth regulator for agriculture and a new scaffold for developing potent inhibitors of SL production.

著者

Koji Ueda Takashi Nagai

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.46, no.3, pp.267-273, 2021-08-20 (Released:2021-08-31)

参考文献数

28

被引用文献数

1

---

We investigated the relative sensitivity of duckweed Lemna minor and six species of algae to seven herbicides, using an efficient high-throughput microplate-based toxicity assay. First, we assessed the sensitivity of L. minor to the seven herbicides, and then we compared its sensitivity to that of previously published data for six algal species based on EC50 values. For five herbicides, the most sensitive species differed: L. minor was most sensitive to cyclosulfamuron: Raphidocelis subcapitata was most sensitive to pretilachlor and esprocarb: Desmodesmus subspicatus was most sensitive to pyraclonil; and Navicula pelliculosa was most sensitive to pyrazoxyfen. Simetryn was evenly toxic to all species, whereas 2,4-D was evenly less toxic, with only small differences in species sensitivity. These results suggested that a single algal species cannot represent the sensitivity of the primary producer assemblage to a given herbicide. Therefore, to assess the ecological effects of herbicides, aquatic plant and multispecies algal toxicity data sets are essential.

著者

Kotaro Koiwai Kana Morohashi Kazue Inaba Kana Ebihara Hirotatsu Kojima Takayoshi Okabe Ryunosuke Yoshino Takatsugu Hirokawa Taiki Nampo Yuuta Fujikawa Hideshi Inoue Fumiaki Yumoto Toshiya Senda Ryusuke Niwa

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.46, no.1, pp.75-87, 2021-02-20 (Released:2021-02-26)

参考文献数

40

被引用文献数

6

---

Insect growth regulators (IGRs) can be developed by elucidating the molecular mechanisms of insect-specific biological events. Because insect molting, and metamorphosis are controlled by ecdysteroids, their biosynthetic pathways can serve as targets for IGR development. The glutathione S-transferase Noppera-bo (Nobo), which is conserved in dipteran and lepidopteran species, plays an essential role in ecdysteroid biosynthesis. Our previous study using 17β-estradiol as a molecular probe revealed that Asp113 of Drosophila melanogaster Nobo (DmNobo) is essential for its biological function. However, to develop IGRs with a greater Nobo inhibitory activity than 17β-estradiol, further structural information is warranted. Here, we report five novel non-steroidal DmNobo inhibitors. Analysis of crystal structures of complexes revealed that DmNobo binds these inhibitors in an Asp113-independent manner. Among amino acid residues at the substrate-recognition site, conformation of conserved Phe39 was dynamically altered upon inhibitor binding. Therefore, these inhibitors can serve as seed compounds for IGR development.

著者

Xusheng Shao Zewen Liu Xiaoyong Xu Zhong Li Xuhong Qian

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.38, no.1, pp.1-9, 2013-02-20 (Released:2013-02-20)

参考文献数

34

被引用文献数

9 84

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Neonicotinoids ushered in a new era of crop protection, and several molecules headed up a billion-dollar industry. As one of the largest agricultural and most populous countries, China plays an essential role in the development of neonicotinoids. This review delves into the production, application and innovation of neonicotinoids throughout China.