著者
Nuraly S. Akimbekov Ilya Digel Dinara K. Sherelkhan Afzalunnessa B. Lutfor Mohammed S. Razzaque
出版者
JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY
雑誌
ACTA HISTOCHEMICA ET CYTOCHEMICA (ISSN:00445991)
巻号頁・発行日
vol.53, no.3, pp.33-42, 2020-06-26 (Released:2020-06-26)
参考文献数
100
被引用文献数
12 57

There is a growing body of evidence for the effects of vitamin D on intestinal host-microbiome interactions related to gut dysbiosis and bowel inflammation. This brief review highlights the potential links between vitamin D and gut health, emphasizing the role of vitamin D in microbiological and immunological mechanisms of inflammatory bowel diseases. A comprehensive literature search was carried out in PubMed and Google Scholar using combinations of keywords “vitamin D,” “intestines,” “gut microflora,” “bowel inflammation”. Only articles published in English and related to the study topic are included in the review. We discuss how vitamin D (a) modulates intestinal microbiome function, (b) controls antimicrobial peptide expression, and (c) has a protective effect on epithelial barriers in the gut mucosa. Vitamin D and its nuclear receptor (VDR) regulate intestinal barrier integrity, and control innate and adaptive immunity in the gut. Metabolites from the gut microbiota may also regulate expression of VDR, while vitamin D may influence the gut microbiota and exert anti-inflammatory and immune-modulating effects. The underlying mechanism of vitamin D in the pathogenesis of bowel diseases is not fully understood, but maintaining an optimal vitamin D status appears to be beneficial for gut health. Future studies will shed light on the molecular mechanisms through which vitamin D and VDR interactions affect intestinal mucosal immunity, pathogen invasion, symbiont colonization, and antimicrobial peptide expression.

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Vitamin D and the Host-Gut Microbiome: A Brief Overview https://t.co/ZayJIaC2y4
ビタミンDが腸のバリア機能を調整し、腸における先天および後天免疫を制御する。 腸内細菌の代謝物がビタミンDレセプターの発現を調整する可能性があり、ビタミンDも腸内細菌叢に影響を与え、抗炎症作用と免疫作用を発揮する可能性があると。 https://t.co/kBfikV8k5N
La vitamina D y el microbioma del intestino huésped https://t.co/1G8JHLKeZT
J-STAGE Articles - Vitamin D and the Host-Gut Microbiome: A Brief Overview https://t.co/hhwrBM966i
J-STAGE Articles - Vitamin D and the Host-Gut Microbiome: A Brief Overview https://t.co/ppelwEIQeg
#VitaminD and the Host-#Gut #Microbiome : A Brief Overview https://t.co/dgKlMF6ycn
¿Existen vínculos entre la #vitaminaD y la salud intestinal? En esta revisión se destaca el papel de la vitamina D en los mecanismos #microbiológicos e #inmunológicos de las enfermedades inflamatorias del intestino. https://t.co/d99BjuRJkR https://t.co/nCRVpTV4CT
#VitaminD D and the Host-#Gut Microbiome: A Brief Overview https://t.co/dgKlMF6ycn
Vitamin D and gut health could be more connected than previously expected. This review updates the role of vitamin D and its nuclear receptor in regulating intestinal barrier integrity and controlling innate and adaptive immunity in the gut https://t.co/tS9LZpTN0s https://t.co/DOXjKdF6Ja

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