著者

Nobuyuki NUKINA Yasuo IHARA

出版者

The Japanese Biochemical Society

雑誌

The Journal of Biochemistry (ISSN:0021924X)

巻号頁・発行日

vol.99, no.5, pp.1541-1544, 1986-05-01 (Released:2008-11-18)

参考文献数

11

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Paired helical filaments (PHF) are unusual neuronal fibers which accumulate progressively in the brain in Alzheimer's disease (AD). The insolubility of PHF in various kinds of solvents enabled us to obtain highly purified PHF, but prevented the application of conventional analytical methods to identify their components. Here we report that antibodies against purified PHF recognize tau protein, a brainspecific microtubule-associated protein, suggesting that a portion of PHF is tau protein.