- 一般社団法人 日本生物物理学会
- 生物物理 (ISSN:05824052)
- vol.57, no.2, pp.090-094, 2017 (Released:2017-03-30)
Hybrid approaches combine computational modeling techniques with low-resolution structural data. Such approaches have proven to be powerful tools to obtain new 3D structural and dynamical information on biological systems. Currently, major applications focus on cryo-EM data. Methods and some applications to construct atomic structural models of new functional states will be reviewed. In addition, possible extension to data from X-ray free electron laser, which currently provides low-resolution data, will be discussed.