著者
Hyun-Kyung Chang Mal-Soon Shin Hye-Young Yang Jin-Woo Lee Young-Sick Kim Myoung-Hwa Lee Jullia Kim Khae-Hawn Kim Chang-Ju Kim
出版者
The Pharmaceutical Society of Japan
雑誌
Biological and Pharmaceutical Bulletin (ISSN:09186158)
巻号頁・発行日
vol.29, no.8, pp.1597-1602, 2006 (Released:2006-08-01)
参考文献数
41
被引用文献数
83 89

Prostate cancer is one of the most common non-skin cancers in men. Amygdalin is one of the nitrilosides, natural cyanide-containing substances abundant in the seeds of plants of the prunasin family that have been used to treat cancers and relieve pain. In particular, D-amygdalin (D-mandelonitrile-β-D-gentiobioside) is known to exhibit selective killing effect on cancer cells. Apoptosis, programmed cell death, is an important mechanism in cancer treatment. In the present study, we prepared the aqueous extract of the amygdalin from Armeniacae semen and investigated whether this extract induces apoptotic cell death in human DU145 and LNCaP prostate cancer cells. In the present results, DU145 and LNCaP cells treated with amygdalin exhibited several morphological characteristics of apoptosis. Treatment with amygdalin increased expression of Bax, a pro-apoptotic protein, decreased expression of Bcl-2, an anti-apoptotic protein, and increased caspase-3 enzyme activity in DU145 and LNCaP prostate cancer cells. Here, we have shown that amygdalin induces apoptotic cell death in human DU145 and LNCaP prostate cancer cells by caspase-3 activation through down-regulation of Bcl-2 and up-regulation of Bax. The present study reveals that amygdalin may offer a valuable option for the treatment of prostate cancers.

言及状況

外部データベース (DOI)

Twitter (262 users, 266 posts, 48 favorites)

「抗癌成分ビタミンB17(アミグダリン)を多く含む果物種子 アンズ、リンゴ、桃、ぶどう、スイカ、ネクタリン、ラズベリー、サクランボ、イチゴ、ブラックベリー、プラム」 癌細胞への有効性は多くの研究が裏付けている https://t.co/h8sqCLmRYC https://t.co/728fah2zbb https://t.co/i7fTNxer6p https://t.co/Ur2Qw3SQyV

収集済み URL リスト