著者
安田 寛
出版者
Japan Society for Biomedical Research on Trace Elements
雑誌
Biomedical Research on Trace Elements (ISSN:0916717X)
巻号頁・発行日
vol.27, no.3, pp.125-140, 2017-01-25 (Released:2017-03-16)
参考文献数
89

The importance of zinc for human health has been recognized since the early 1960s, but today there is little concern about zinc deficiency in developed countries. We measured the zinc concentration in hair from 28,424 Japanese subjects (18,812 females and 9,612 males) and found that 1,754 individuals (6.17 %) had zinc concentrations lower than the -2 standard deviations level (86.3 ppm) of its control reference range, which qualifies as zinc deficiency. A considerable proportion of elderlies and children (20 % or more) were found to have marginal to severe zinc deficiency. A minimum zinc concentration of 9.7 ppm was observed in a 51-year-old woman; this concentration was approximately 1/13 of the mean reference level. The prevalence of zinc deficiency in adults increased with aging from 1-2 % in the young to a peak of 19.7 % in the 8th decade of life, and decreased to 3.4 % or less in the longevities above 90-year-old. The prevalence of zinc deficiency in children aged 0–9 years was 29.9 % in males and 33.8 % in females.In the study for 1,967 children with autistic disorders (1,553 males and 414 females), 584 individuals (29.7 %) were found deficient in zinc, and its deficiency rate in infantile group aged 0–3 years was 43.5 % in male and 52.5 % in female. Next to zinc, 347 (17.6 %) and 114 (5.8 %) individuals were deficient in magnesium and calcium, and 2.0% or less in the other essential metals such as iron, cupper or manganese. In contrast, 339 (17.2 %), 168 (8.5 %) and 94 (4.8 %) individuals were found suffering from high burden of aluminum, cadmium and lead, and 2.8 % or less from mercury and arsenic burden. These findings suggest that infantile zinc deficiency and toxic metal burdens may epigenetically play pivotal roles as environmental factors in the pathogenesis of autism spectrum disorders (ASDs) and that metallomics approach helps lead to early screening and intervention/treatment of the neurodevelopment disorders.This review demonstrates that infant and elderly are liable to zinc deficiency and that many infants with autistic disorders are suffering from zinc deficiency and toxic metal burdens, suggesting the presence of “infantile time window” in neurodevelopment and probably for therapy. These findings suggest that early assessment and intervention of zinc deficiency is possibly effective for infants with autistic disorders and essential for normal development, health and longevity.

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細胞内亜鉛状態を反映するとは限らないことが知られており、血清・血漿中亜鉛濃度を指標とする既存の臨床検査では、亜鉛の栄養状態を的確に測るのは困難であると言われている。 https://t.co/EkcK4N0CSn
これらの結果は、亜鉛が不足すると有害金属が体内に蓄積することを示唆している。 亜鉛が有害金属に対抗するミネラルであることを裏付けている。 亜鉛不足の現状:早期発見・早期介入の必要性 #亜鉛 https://t.co/hKiKQlZEaa
有害金属の異常蓄積は亜鉛不足と関連し、 亜鉛濃度と鉛濃度との間には有意な負の相関関係が見られた。同様の関係が、亜鉛濃度とアルミニウム・カドミウム濃度との間にも認められた。これらの結果は、亜鉛が不足すると有害金属が体内に蓄積することを示唆している。 https://t.co/hKiKQlZEaa

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