著者
Hironori Imano Hiroyasu Iso Akihiko Kitamura Kazumasa Yamagishi Mina Hayama-Terada Isao Muraki Takeo Okada Mitsumasa Umesawa Tetsuya Ohira Tomoko Sankai Renzhe Cui Takeshi Tanigawa Masahiko Kiyama on behalf of the CIRCS Investigators
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
(Released:2018-02-14)
参考文献数
44

Background:The effect of postprandial glucose on the risk of cardiovascular disease has been emphasized, but it is controversial whether nonfasting glucose is related to incident stroke and its types.Methods and Results:We investigated the associations of nonfasting glucose with incident stroke and its types among 7,198 participants aged 40–74 years from the Circulatory Risk in Communities Study, enrolled in 1995–2000. We estimated multivariable hazard ratios (HR) using Cox proportional hazard models. Over a median follow-up of 14.1 years, 291 cases of total stroke (ischemic strokes: 191 including 109 lacunar infarctions) were identified. Nonfasting glucose concentration was associated with greater risk of incident total stroke, ischemic stroke and lacunar infarction when modeled categorically (for prediabetic type: 7.8–11.0 mmol/L vs. normal type: <7.8 mmol/L among all subjects, HR for lacunar infarction was 2.02, 95% confidence interval (CI): 1.19, 3.43) or continuously (per one standard deviation increment among all subjects, HR for lacunar infarction was 1.29, 95% CI: 1.15, 1.45). Diabetic type showed similar results. Population attributable fractions of nonfasting hyperglycemia were 13.2% for ischemic stroke and 17.4% for lacunar infarction.Conclusions:Nonfasting glucose concentration, either as a diagnosis of prediabetic and diabetic types or as a continuous variable, proved to be an independent predictor significantly attributed to incident total stroke, especially ischemic stroke and lacunar infarction, in the general population.

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【日本7198名14.1年 [中央値] 観察CIRCS:非空腹時血糖「<140mg/dL」に比べ「140-198mg/dL」で、脳卒中HRは1.84 [95%CI 1.33-2.55]。脳梗塞リスク増が著明】 Circ J https://t.co/rj27I59P9C

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