著者
Yohei Okada Sho Komukai Tetsuhisa Kitamura Takeyuki Kiguchi Taro Irisawa Tomoki Yamada Kazuhisa Yoshiya Changhwi Park Tetsuro Nishimura Takuya Ishibe Yoshiki Yagi Masafumi Kishimoto Toshiya Inoue Yasuyuki Hayashi Taku Sogabe Takaya Morooka Haruko Sakamoto Keitaro Suzuki Fumiko Nakamura Tasuku Matsuyama Norihiro Nishioka Daisuke Kobayashi Satoshi Matsui Atsushi Hirayama Satoshi Yoshimura Shunsuke Kimata Takeshi Shimazu Shigeru Ohtsuru Taku Iwami
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-21-0675, (Released:2021-11-02)
参考文献数
52
被引用文献数
2

Background:The hypothesis of this study is that latent class analysis could identify the subphenotypes of out-of-hospital cardiac arrest (OHCA) patients associated with the outcomes and allow us to explore heterogeneity in the effects of extracorporeal cardiopulmonary resuscitation (ECPR).Methods and Results:This study was a retrospective analysis of a multicenter prospective observational study (CRITICAL study) of OHCA patients. It included adult OHCA patients with initial shockable rhythm. Patients from 2012 to 2016 (development dataset) were included in the latent class analysis, and those from 2017 (validation dataset) were included for evaluation. The association between subphenotypes and outcomes was investigated. Further, the heterogeneity of the association between ECPR implementation and outcomes was explored. In the study results, a total of 920 patients were included for latent class analysis. Three subphenotypes (Groups 1, 2, and 3) were identified, mainly characterized by the distribution of partial pressure of O2(PO2), partial pressure of CO2(PCO2) value of blood gas assessment, cardiac rhythm on hospital arrival, and estimated glomerular filtration rate. The 30-day survival outcomes were varied across the groups: 15.7% in Group 1; 30.7% in Group 2; and 85.9% in Group 3. Further, the association between ECPR and 30-day survival outcomes by subphenotype groups in the development dataset was as varied. These results were validated using the validation dataset.Conclusions:The latent class analysis identified 3 subphenotypes with different survival outcomes and potential heterogeneity in the effects of ECPR.

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外部データベース (DOI)

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初期波形VFの院外心停止患者で3つのサブタイプを潜在クラス分析で特定した。 このサブタイプは予後が異なり、また、ECPRの実施と予後との関連性に不均一性が見られた。 By 岡田遥平 @OkadaYohei https://t.co/zZk6zwvAhq #circ_j https://t.co/B93XnuVJ8J
Latent class analysis identified 3 subphenotypes in OHCA patients with initial VF. The subphenotypes have different outcomes and heterogeneity of association between ECPR and outcome. By Yohei Okada @OkadaYohei https://t.co/zZk6zwvAhq #circ_j https://t.co/wSxXuqgR34
https://t.co/ZUL50mtcTl
潜在クラス分析でVF院外心停止のサブフェノタイプを分類し、ECPRと予後の関連の異質性を評価した論文を出版しました! Clinical Phenotyping of Out-of-Hospital Cardiac Arrest Patients With Shockable Rhythm ― Machine Learning-Based Unsupervised Cluster Analysis ― https://t.co/WZPEBA25YE

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