著者
Takaaki Ishikawa Takahiro Shinozaki Kazutaka Shimoda
出版者
日本臨床精神神経薬理学会
雑誌
Clinical Neuropsychopharmacology and Therapeutics (ISSN:18848826)
巻号頁・発行日
vol.5, pp.18-22, 2014-07-15 (Released:2014-07-15)
参考文献数
11

The patient was a 67-year-old man. After the patient received a diagnosis of schizophrenia, various antipsychotics were prescribed but did not improve symptoms. However, 18 mg/day aripiprazole (APZ) was found to be highly effective and enabled the patient to continue treatment on an outpatient basis. Two weeks after prescribing clarithromycin for fever and cough, he was readmitted to our psychiatric ward because of anuresis and deterioration of bradykinesia and salivation. Biochemical analysis revealed elevated serum creatine phosphokinase (26060 U/I) and creatinine (2.2 mg/dL). On admission, the patient had a high blood concentration of APZ and its metabolite(s). APZ was therefore discontinued, but the concentration remained elevated until day 8. Hemodialysis was started on day 4 to treat persistent renal dysfunction. The patient's CYP2D6 genotype was CYP2D6*10/CYP2D6*10. The elevated APZ levels may have resulted from the inhibitory action of clarithromycin on CYP3A4 combined with the lower inherent CYP2D6 enzymatic activity of the CYP2D6*10/CYP2D6*10 genotype.

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教室の石川高明先生の症例報告がClinical Neuropsychopharmacology and Therapeutics掲載されました。Aripiprazoleとerythromycinの併用によって横紋筋融解症を呈した症例です。CYP2D6遺伝子型が:1/*10という中間代謝者だというところがポイントです。https://www.jstage.jst.go.jp/article/cnpt ...
石川高明先生の症例報告がClinical Neuropsychopharmacology and Therapeutics掲載されました。Aripiprazoleとerythromycinの併用によって横紋筋融解症を呈した症例です。CYP2D6遺伝子型が:1/*10という中間代謝者だというところがポイントです。https://www.jstage.jst.go.jp/article/cnpt/5/ ...

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未読論文メモ http://t.co/taMDlnPQGF http://t.co/JSAsHHUWOG https://t.co/k5yI062z2t https://t.co/FkyEX5c5No
メモ:未読論文 https://t.co/FkyEX5c5No https://t.co/k5yI062z2t http://t.co/cBJE7JH2XP http://t.co/ujLhM4c4hO
Rhabdomyolysis After the Administration of Clarithromycin in a Japanese Schizophrenic Patient Receiving Aripiprazol… http://t.co/LX2e3pI1Qc
Rhabdomyolysis After the Administration of Clarithromycin in a Japanese Schizophrenic Patient Receiving Aripiprazole:https://t.co/lFWGpssIjA
http://t.co/LX2e3pqqI8
CYP2D6*10変異をもつaripiprazole服用患者においてClarithromycin併用によって血中濃度上昇→横紋筋融解症が疑われた症例報告、獨協医大。 こういう報告を見るとCAMの薬物相互作用の怖さを再認識します。 https://t.co/4KKBvf4lGc
CYP3A4*10変異をもつaripiprazole服用患者においてClarithromycin併用によって血中濃度上昇→横紋筋融解症が疑われた症例報告、獨協医大。 こういう報告を見るとCAMの薬物相互作用の怖さを再認識します。 https://t.co/4KKBvf4lGc

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