- The Pharmaceutical Society of Japan
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- vol.66, no.2, pp.105-115, 2018-02-01 (Released:2018-02-01)
The divergent total syntheses of three types of heteropolycyclic natural products, namely gelsedine-type alkaloids, amathaspiramide alkaloids, and erythrina alkaloids, are outlined. A strategy involving a late-stage pluripotent common synthetic intermediate prepared via original and innovative transformations was employed. A brief description of the philosophy and criteria for choosing the synthetic targets and common synthetic precursors, as well as details regarding the development of the overall synthetic schemes from a common intermediate are discussed.