- 著者
- KAZUO OGAWA TADAFUMI TERADA YOSHIYUKI MURANAKA TOSHIHIRO HAMAKAWA SHUNSAKU OHTA MASAO OKAMOTO SETSURO FUJII
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.35, no.8, pp.3276-3283, 1987-08-25 (Released:2009-10-19)
- 参考文献数
- 19
- 被引用文献数
- 5 8
trans-and cis-2-Diazo-1- (4-alkylcyclohexyl) -1-ethanones were reacted with arenesulfonic acids to afford the corresponding 2- (4-alkylcyclohexyl) -2-oxoethyl arenesulfonates. The esteraseinhibitory activity and hypolipidemic effect of the arenesulfonates were examined, and it was found that in most cases, the trans-isomers were more active than the corresponding cis-isomers.Stereoselective syntheses of several biologically potent trans-isomers (trans-3) were also developed.