- 著者
- 紺野 勝弘 尾島 克二 林 貴昭 高山 浩明
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.40, no.5, pp.1120-1124, 1992-05-25 (Released:2008-03-31)
- 参考文献数
- 17
- 被引用文献数
- 15 24
An alternative synthesis of the title compound 2, a highly potent analog of 1α, 25-dihydroxyvitamin D3 (1), is described. Starting with 1α, 3β-bis[(tert-butyldimethylsilyl)oxy]androst-5-ene (8), 2 was obtained in 3.8% total yield through 10 steps. This method provides compound 2 in much higher yield than that reported previously.