- 著者
- Liying Dong Shasha Hu Jianjun Gao
- 出版者
- International Research and Cooperation Association for Bio & Socio-Sciences Advancement
- 雑誌
- Drug Discoveries & Therapeutics (ISSN:18817831)
- 巻号頁・発行日
- vol.14, no.1, pp.58-60, 2020-02-29 (Released:2020-03-08)
- 参考文献数
- 19
- 被引用文献数
- 939
The SARS-CoV-2 virus emerged in December 2019 and then spread rapidly worldwide, particularly to China, Japan, and South Korea. Scientists are endeavoring to find antivirals specific to the virus. Several drugs such as chloroquine, arbidol, remdesivir, and favipiravir are currently undergoing clinical studies to test their efficacy and safety in the treatment of coronavirus disease 2019 (COVID-19) in China; some promising results have been achieved thus far. This article summarizes agents with potential efficacy against SARS-CoV-2.
言及状況
外部データベース (DOI)
Twitter (152 users, 175 posts, 128 favorites)
@JulSaun @barriere_dr @amandine_begot @Bruce_Toussaint @MaximeSwitek @raoult_didier @fluidloading @JulienPain @MathieuMolimard @TroncheBiais @tristanmf @docprimum @RReichstadt @Drmartyufml @gouvernementFR Allez on y va...
Chine https://t.co/vDczEtGZmI
@arikouts @metallimoi @bibinhafc @migg2a @DanielFfry @FredGaulois @andrebercoff https://t.co/6t5XOncycn
500 mg (300 mg for chloroquine) each time, 2 times/day
200 mg each time, 3 times/day
Method of administration
Vapor inhalation
Oral
Intravenous infusion
Oral
Oral
Duration of treatment
No more than 10 days
@LFlibidi https://t.co/RYCrKbjA9x
@ALENA_DOS @NobodyLies @zxcvb11130 Почитайте данные иностранных (подчеркиваю) исследований.
https://t.co/lLi5OrR000
Поищите по слову arbidol и обнаружите что вполне себе небесполезен.
@JolieEmile @alexsitou @cavousf5 1/La chine
https://t.co/wX5daSsHxC
2/La Belgique
https://t.co/jueyZ7n2O8
3/L’Italie
https://t.co/RUyfslaNGY
@ProfitJim @sebsebseb1975 @louiseWUND @raoult_didier Tout est sur son site mais je vais te mâcher le taf
https://t.co/0XOsBtOfwz
Et après je te laisse chercher sur leurs site
@Drakspartan Es Ruso-Japones, a la fecha tiene resultados prometedores, pero aun faltan más estudios. https://t.co/yIUl8sRuOW
Check it out a related paper, but I can't see/found the clinical trial. Aquí un artículo interesante que aclara un poco el horizonte; sin embargo, no veo/encuentro el ensayo clínico: https://t.co/hZOEVEf1rP
2/. En 2 estudios realizados en China que han incluido un total de 340 pacientes con COVID19, favipiravir ha acelerado la curación, con remisión virológica y mejoría radiológica. Es decir, muy "parecido" al efecto del remdesivir.
Fuente de estudios;
https://t.co/YqRt40bg3m
@MarcoWaterworms @mynameisazerty @JeanMarcTrappie @Crohnfighter @lilitouffe @BFMTV Chine https://t.co/El3GyyWeg8
Pays-Bas https://t.co/5gUFFlKjMH
Iran https://t.co/nEjEZRKnyv
Belgique https://t.co/OzBuEPjyK0
Italie (Lombardie) https://t.co/EjWKFPh7XG
USA (New York) https://t.co/B5p4PiXdYQ
Corée https://t.co/icUovTMw7b
Inde https://t.co/2zSR4RKdvN
https://t.co/d5WtikNA2u
@toni_bonum @romalin46 @Samuel_Mondy @zenutopia1 @One_romOne @sun_in_paris @ElChaton6 @Fraslin @Financialafrik @raoult_didier Corée
https://t.co/JWeoxLa91P
Chine
https://t.co/HPitoGKL1B
@yammerapple https://t.co/9RVjFbB4bm
Interferon alpha 2b:
Chinese guidelines for COVID-19 have used 5 million IU IFN-α 2b, twice per day, nebulized in 2mL sterile water.
https://t.co/4J1XNvK4ko
https://t.co/H5UAyU4sde
https://t.co/F0FFg625id
https://t.co/g6j2kRe8VE
https://t.co/vlPswac11E
J-STAGE Articles - Discovering drugs to treat coronavirus disease 2019 (COVID-19) https://t.co/Yu6rv7yXpZ
@azadisalive https://t.co/m9Ewj3oFgC
@drjahanpur https://t.co/am5mjzfkgC
این مقاله صفحه ۵۹ اثر مثبت دارو میگه، هنوزم کسی پسش نگرفته! البته من اینجا نیستم به جهت اثبات علمی داستان تخصصیم ندارم. از توییت اولم بخونید،میبینید که مهمترین داستان واسم دستور وزیر محترم بهداشت به برخورد با دکتر هاشمیان بوده! امیدوارم تکذیب بشه همین
@kaurisalonen A recent summary of treatment studies: https://t.co/YA7gGy07Rd
I'm guessing first working treatments will be announced in around a month.
A working vaccine - end of year? 12 months? There's a substantial risk that vaccine is never finished if treatments work well enough.
@Jean_no Résumé en anglais du consensus chinois.
Montrez le aux médecins et demandez leur d'interroger l'ordre des médecins sur sa position actuelle
https://t.co/STHHV6y2Pa
@AanonYiim @DamienDole @libe Allez, rien que pour la première source, sur la Chine. (https://t.co/SPWtWA8KQR)
Voici les véritables traitements (en photo). Première ligne, première vérif, ce tableau est faux. Dommage. https://t.co/31lS4W9lG7
... de ne pas comprendre le chemin d'arrivée dans les Guidelines chinoises de la Chloroq.
L'e-pub https://t.co/urI4WntYrC était la probable "raison", mais les 2 liens suivants complètent la perspective :
https://t.co/F8oRciVxic
https://t.co/Tp3bOKcF0q
...
@dr_l_alexandre c'est vrai que les francais ont toujours de l'avance...
https://t.co/dxvOFEgltN
@raoult_didier The efficacy and safety of these candidate drugs
in the treatment of COVID-19 need to be confirmed in
further preclinical and clinical trials.
Essai en chine votre premier lien.
https://t.co/MsRRYv9ZQ3
Discovering drugs to treat coronavirus disease 2019 (COVID-19) https://t.co/zC2Q63FhFJ
@Yusuf_Cenik_ @DrMetinCakir Türkiyede dün gece hastanelere yollandı ve kullanılmaya başladı sanırım.
Konunun uzmanlarının araştırması gereken konular bunlar. Ama Pubmed üzerinden klinik deneyler ve etkileri üzerine oldukça çok makaleye ulaşmak mümkün.
https://t.co/u8oIwzfBRe
@cris_cersei No Cris. (Almeno lo spero...) Si sta lavorando febbrilmente in tutto il mondo per identificare i protocolli di terapia più efficaci. https://t.co/pw66EzyLh4 https://t.co/FxcKjT3iTE
@OpheliaNym @PLWilds Non è così. L’AIFA ha confermato quello che è documentato dall’esperienza clinica. Ad oggi nessun farmaco può essere considerato “approvato per la terapia”: siamo ancora all’uso sperimentale. Comunque, ieri ha autorizzato la sperimentazione dell’Avigon. https://t.co/pw66EzyLh4 https://t.co/7iZTiQTYBs
@RobertoBurioni Ma per favore... La facevo più intelligente. Pensa davvero sia stato scelto per un video o magari per degli studi effettuati: https://t.co/iWUop8ShUs
Buat anak2 farmasi bisa pakai artikel ini untuk bahan diskusi dan elaborasi data2 praktik & guideline yang disertakan. Ada yg di garis depan, ada yg di belakang telaah update terbaru ke rekan2 garis depan https://t.co/dXkGiw83I0
@MJPC21 @CameliaCAndrade @danieljadue lo puso a disposición de los hospitales públicos, lo dije en mi tw anterior. Creo que él lo explica increíblemente en su columna. Además te copio 2 papers que están buenos. https://t.co/9tskXjW3Zo . https://t.co/xWoBB5er48
https://t.co/WG6y8inQcP
Discovering drugs to treat coronavirus disease 2019 (COVID-19)
https://t.co/DUprbQbpRA
#COVID19 #ClubQuarantine #CoronovirusPandemic
@disinformatico @Laura69094159 Va ovviamente testato (come.gli altri)
https://t.co/w07lDOz3mQ
@nonelarena fate chiarezza, basta far vedere la parte dello studio che vi ho inviato dove si parla di Avigan o Favipiravir. Lo studio è stato fatto in Cina così date un informazione corretta agli spettatori! Pagina 2 primo paragrafo Grazie https://t.co/c65TyVJhx8
@preglias Buonasera magari lo ha già letto, ma vista la discussione all’Arena...
https://t.co/c65TyVJhx8
@nonelarena https://t.co/c65TyVJhx8
@Keynesblog @neXtquotidiano https://t.co/w07lDOz3mQ
@andreasso1951 Il brevetto del farmaco è stato acquistato da una compagnia cinese, ed ora stanno tentando di migliorarlo..
https://t.co/geDILKGKB6
Reference
Liying Dong, Shasha Hu, & Jianjun Gao. (2020). Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug Discoveries & Therapeutics, 14(1), 58–60. https://t.co/KHQMpLfszU
concentration (EC50), 0.77 μM; half-cytotoxic concentration (CC50) > 100 μM; SI > 129.87) (8).
Liying Dong, Shasha Hu, & Jianjun Gao. (2020). Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug Discoveries & Therapeutics, 14(1), 58–60. https://t.co/KHQMpLfszU
Liying Dong, Shasha Hu, & Jianjun Gao. (2020). Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug Discoveries & Therapeutics, 14(1), 58–60. https://t.co/KHQMpLfszU
Liying Dong, Shasha Hu, & Jianjun Gao. (2020). Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug Discoveries & Therapeutics, 14(1), 58–60. https://t.co/KHQMpLfszU
200 mg for adults, 3 times/day. The duration of treatment is no more than 10 days.
Liying Dong, Shasha Hu, & Jianjun Gao. (2020). Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug Discoveries & Therapeutics, 14(1), 58–60. https://t.co/KHQMpLfszU
Liying Dong, Shasha Hu, & Jianjun Gao. (2020). Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug Discoveries & Therapeutics, 14(1), 58–60. https://t.co/KHQMpLfszU
Several promising COVID-19 treatments in various stages of testing, including remdesivir, favipiravir & darunavir. (Testing does not mean a cure is here, and none of these are vaccines). Download the full article :
https://t.co/1zxAkb7bhH https://t.co/iEe1zGWIT1
Another https://t.co/TxuV8GdSan
Articolo in inglese su #pubmed #Avigan #COVID19 #trial #drug https://t.co/BmaMvT6tJB
https://t.co/YAHSYB2OG0
@__poseidon_ c'est en cours d'étude , ça semble prometteur https://t.co/0PN1QBA0Lb
J'essaie de voir les sources : en voici qqunes.
(sinon, c'est l'homme qui a vu l'ours... Et franchement, j'en ai soupé de ces approches)
Je ne tire aucune conclusion pour l'instant (pas compétent pour..)
https://t.co/3UeXE39mip
https://t.co/hPCc5nRduh https://t.co/MxU43R1QFv
アビガンの有効性の論文です。
合計80人の患者がこの臨床試験に登録。35人の患者がファピラビルで治療。
結果は、ウイルス除去の観点から、治療後のファピラビル試験群の患者のウイルス除去時間の中央値（ウイルス核酸陰性）は対照群よりも有意に短いことを示した。
https://t.co/K5MDIrgArr
STUDY RELATED TO THIS TREATMENT DONE IN JAPAN:
https://t.co/y8Dve4KAyn
#Covid19treatmetns #Covid19 #Covid19cure #Coronavirus
@MonaKamal788 https://t.co/s4iMvqCJyD
Haydi hayırlısı:
https://t.co/kTvIDqeqPt
Discovering drugs to treat coronavirus disease 2019 (COVID-19)
https://t.co/eCDwCfoXYF
#کروناویروس
https://t.co/y5lv9mnZL3
@chelanbytahoe I saw that last night in my 3:00am readings! Here's a link to a journal article that discusses the efficacy of favipiravir and a few other drugs. Click on the red download PDF link. https://t.co/cNMEydP31H
Des nouvelles du front curatif : https://t.co/fW0uLI0VaQ
@PotardDechaine Pas tout à fait. Les chinois avaient déjà publié leur résultats préliminaires sur de vrais études cliniques à ce moment là mais beaucoup n'y ont pas cru.
#coronavirus #choloroquine @IHU_Marseille
https://t.co/XjtiEjJXQC
https://t.co/KuXlbHYqlU
Chloroquine in chinese #coronavirus treatment guidelines - https://t.co/mgXW3r0NTF
free, no paywall. Released: March 08, 2020
Great references in this article too.
Do not @ me with all your negative bull. Read it yourself/whine to the GOP
Discovering drugs to treat coronavirus disease 2019 (COVID-19)
https://t.co/RQnlTxnozA
@Abu_adam0000 https://t.co/s4iMvqCJyD
Dong L, Hu S, Gao J. Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug Discov Ther. 2020;14(1):58–60. doi:10.5582/ddt.2020.01012
https://t.co/iiOsMZV9HV
Yararlanılan makaleler
@cuneytozek Discovering drugs to treat coronavirus disease 2019
https://t.co/B45IQeEUdr
Discovering drugs to treat coronavirus disease 2019 (COVID-19)
https://t.co/T5Gno1LaqP
Étude des traitements en cours https://t.co/sO6s4REyun
Discovering drugs to treat coronavirus disease 2019 (COVID-19)
https://t.co/CbJtTMV6ZH
Discovering Drugs to treat Coronavirus Disease
https://t.co/CbJtTMV6ZH
https://t.co/CbJtTMV6ZH
@julie_justo @ConanMacDougall @JGPharmD @mmPharmD @jkortwine @MattRico_PharmD @ABXsteward @not_that_CDC @CardiacRX @accpinfdprn @StewardlyPharmD @SIDPharm @jpogue1 @IDPharmProf @emilylheil @ErinMcCreary I found this article and it's references to be helpful
#COVID19
https://t.co/3k8jQZCaJ4
Several drugs including chloroquine, arbidol, remdesivir, and favipiravir are currently undergoing clinical studies to test their efficacy and safety against #COVIDー19 #CoronaVirusUpdates #Covid_19 https://t.co/IyjgGYr8CE
https://t.co/Ocp8GkFing
Interesante artículo. Antivirales frente #COVID-19 J-STAGE Articles - Discovering drugs to treat coronavirus disease 2019 (COVID-19) https://t.co/XTDAxn9EcN
@aidybarnett Good Q. China has been doing several trials for #COVID19 treatments, so must have had expedited funding, governance & ethics processes to do that - https://t.co/iZtc0bptoD
https://t.co/TKeHs1Atvw
#Covid_19
2/ There are a great many efforts to find medications useful in treatment of severe #COVID19; the ones named here are only some of the ones currently being tried or in formal trials. Note the attempt with protease inhibitors (Kaletra) too.
https://t.co/0vHk3tXXL4 https://t.co/iWQ9fd2nn6
ใครนอนดึก เรามีสรุปเรื่อง Therapeutic option for COVID-19 มาฝาก
สั้นๆ สรุปชื่อยาที่มี inhibitory effect และ side effect 2 slides
Reference: Dong L, et al. Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug Discov Ther. 2020;14(1):58-60
https://t.co/As6AV4s3cW https://t.co/HSYjU3ywbN
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