著者
Yasuhiro Ito Minoru Kihara Yuuki Takamura Kaoru Kobayashi Akihiro Miya Mitsuyoshi Hirokawa Akira Miyauchi
出版者
(社)日本内分泌学会
雑誌
Endocrine Journal (ISSN:09188959)
巻号頁・発行日
vol.59, no.7, pp.539-545, 2012 (Released:2012-07-31)
参考文献数
40
被引用文献数
10 16

Age is an important prognostic factor of papillary thyroid carcinoma (PTC). In this study, we investigated the prognosis and prognostic factors of PTC in patients younger than 20 years. We enrolled 110 patients who underwent initial surgery at Kuma Hospital between 1987 and 2008. Tumor size > 4 cm, metastatic node ≥ 3 cm, and significant extrathyroid extension were more frequently detected in 8 patients with distant metastasis at diagnosis than in 102 patients without distant metastasis. Ten- and 20-year lymph node recurrence-free survival (LN-RFS) and distant recurrence-free survival (DRFS) rates were 84 and 80%, and 95 and 89%, respectively. Metastatic node ≥ 3 cm, age ≤ 16 years, tumor size > 4 cm, and male gender affected LN-RFS, and the former two had an independent prognostic value in multivariate analysis. Metastastic node ≥ 3 cm, significant extrathyroid extension, age ≤ 16 years, tumor size > 4 cm, and a male gender predicted a poor DRFS, and the former two were independent prognostic factors. To date, only 2 patients have died of PTC. These findings suggest that, in the subset of PTC patients younger than 20 years, metastatic node ≥ 3 cm, significant extension, and age ≤ 16 were important signs of aggressiveness of carcinoma, and careful treatment is necessary for patients with these characteristics, although the cause-specific survival was excellent.

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外部データベース (DOI)

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Prognosis and prognostic factors of papillary thyroid carcinoma in patients under 20 years(隈病院、2012年)… https://t.co/pawiUUCoom
小児甲状腺乳頭がんの治療:予後因子 https://t.co/VJo7hCsnsA ItoY. (2012) "Prognosis and prognostic factors of papillary thyroid carci… https://t.co/8xGsfrAkGs
Ito Y. (2012) "Prognosis and prognostic factors of papillary thyroid carcinoma in patients under 20 years" https://t.co/kBlvZR6LiC
@drsteppenwolf 隈病院20歳未満初回手術例(87年~08年)による予後因子研究 https://t.co/rzLfSoiP9Hの全文PDFで、541頁のTable1はどう読みますか?
Ito Y. (2012) "Prognosis and prognostic factors of papillary thyroid carcinoma in patients under 20 years" https://t.co/aMl852dMRZ
Ito (2012) "Prognosis and prognostic factors ..." https://t.co/aMl851WJPZ より 「Released online in J-STAGE as advance publication Apr.3, 2012」
Ito Y (2012) "Prognosis and prognostic factors of papillary thyroid carcinoma in patients under 20 years" https://t.co/aMl851WJPZ
Ito Y. (2012) "Prognosis and prognostic factors of papillary thyroid carcinoma in patients under 20 years" https://t.co/aMl851WJPZ
20歳以下の死亡例 伊藤病院 0/57 http://t.co/n63Pc5n9lp 隈病院 2/110 https://t.co/4oXe3RBGDm QTこの医師の話は「大人」だったよ。福島医大の鈴木教授は何と言いましたか?→「治療歴のある医師は、甲状腺癌は死ななないなん
20歳以下の甲状腺癌の予後因子 リンパ節3cm以上、腫瘍径4cm以上、明らかな甲状腺外進展、16歳以下、男性の要素が遠隔転移再発予後に関係した。 https://t.co/6UwPNOSiEi
Ito Y. (2012) "Prognosis and prognostic factors of papillary thyroid carcinoma in patients under 20 years" https://t.co/aMl852dMRZ
@todaidon その後、隈病院と伊藤病院の小児甲状腺癌追跡調査の論文が見つかりまして、 ①https://t.co/4oXe3RBGDm ②https://t.co/STLbEoRAsb ③ http://t.co/wpKEbJhPzY  
隈病院87―2008年の小児甲状腺癌の経過: 102例中死亡は2例。このデータでは3cm以上のリンパ節転移、被膜外への進展、腫瘍径4cm以上、男性、16歳以下、を予後因子として挙げている。 https://t.co/6UwPNOSiEi
@pririn_ まず再発率の多寡ついては、術式の選択(全摘なのか葉切除)・術後の放射線治療の有無により違ってくると思います。Ito(2012) https://t.co/aMl852dMRZ の日本のデータではリンパ節での再発が20%、遠隔部位での再発が11%となっています。
@myen ItoY. (2012) "Prognosis and prognostic factors of papillary thyroid carcinoma in patients under 20 years" https://t.co/lVdq6SsX

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