28 0 0 0 OA Glyphosate

著者
Food Safety Commission of Japan
出版者
Food Safety Commission, Cabinet Office, Government of Japan
雑誌
Food Safety (ISSN:21878404)
巻号頁・発行日
vol.4, no.3, pp.93-102, 2016 (Released:2016-09-30)
被引用文献数
1

The Food Safety Commission of Japan (FSCJ) conducted a risk assessment of glyphosate (CAS No. 1071-83-6), an amino acid herbicide, based on results from various studies. Major adverse effects of glyphosate were observed on reduced gain of body weight, GI tract (diarrhea, increased cecum weight, bowel dilatation, thickening of intestinal mucosa), and liver (increased alkaline phosphatase (ALP), hepatocellular hypertrophy). Glyphosate had no neurotoxicity, carcinogenicity, reproductive toxicity, teratogenicity, and genotoxicity. As the whole, the lowest value among no-observed-adverse-effect levels (NOAELs) was 100 mg/kg bw/day obtained in the 90-days and one-year toxicity studies in dogs, and in the developmental toxicity studies of rabbits. FSCJ thus established an acceptable daily intake (ADI) for glyphosate at 1 mg/kg bw/day, applying a safety factor of 100 to the NOAEL. The lowest NOAEL for adverse effects elicited by a single oral administration of glyphosate was 1,000 mg/kg bw observed in an acute toxicity studies in rats and mice. It is thus unnecessary to specify an acute reference dose (ARfD), due to the exceeding of the cut off level (500 mg/kg bw).

言及状況

外部データベース (DOI)

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@autismepi @KHefferon @Kenn_QBE @moschettopres @JohnHard3 Gly is unlikely to be carcinogenic according to: Switzerland https://t.co/VfohJE8TYT Australia https://t.co/B31XiY9WhW Canada https://t.co/6dgX4YyMm4 New Zealand https://t.co/yrj5CfA8pc Japan https://t.co/9LnSpDYOPy WHO & UN https://t.co/VnpJBGOSau But wait there’s more!!!
@ekogaia @WyoWeeds @drdevangm Glyphosate unlikely to be carcinogenic according to: Switzerland https://t.co/KnZvoCMafd Australia https://t.co/ESU3pZ817J Canada https://t.co/xv0wHDBMkx New Zealand https://t.co/eLs08EXs62 Japan https://t.co/IKyIPZkucH WHO&UN https://t.co/Q0R2CMUsF9 EFSA https://t.co/Ta3nvIdWIN
Glyphosate unlikely to be carcinogenic according to: Switzerland https://t.co/KnZvoCMafd Australia https://t.co/ESU3pZ817J Canada https://t.co/xv0wHDBMkx New Zealand https://t.co/eLs08EXs62 Japan https://t.co/IKyIPZkucH WHO&UN https://t.co/Q0R2CMUsF9 EFSA https://t.co/Ta3nvIdWIN https://t.co/bpnFT88VPG
@AlainPannetier @dingologue https://t.co/9WCCXYcdxL "Glyphosate had no neurotoxicity, carcinogenicity, reproductive toxicity, teratogenicity, and genotoxicity"
@Guy__Moux @StephaneMandard Et depuis quand le glyphosate serait "perturbateur endocrinien" ?
@DurocYann @GeWoessner @Naismtz7 @AmandineBlanch9 @Auto_Math @emma_ducros @virginienini1 @FallaitPasSuppr Je met là la synthèse de tous les rapports d'agences sanitaires mondiales sur le glyphosate Celle du Japon est très claire sur le côté tératogénicité : https://t.co/hnqT3PuuPp https://t.co/WhlUqjRwyK
@BertrandM19 @Eul_Stephane @brutofficiel 2/ Et le reste du monde https://t.co/p9fTkleUAW https://t.co/7Ge5zDxlu7 https://t.co/9BX8pEWb0R https://t.co/fmsyUwMSyN
@Eul_Stephane @GaeBrugiere @zeismlb @ze_fisch @rvigneaux @AEGRW @EliseLucet La FSCJ : https://t.co/NvvXNt1SVa https://t.co/cFOccwf5hi
@sppozueco @mcalerom @Ladys_y_lords @411emilio @jmmulet @EFSA_EU Informe Japón: https://t.co/dpWJO9NTHK Informe ECHA: https://t.co/1eQ8seZyGl Y aún hay más.
@Dr_Stephane Concernant la nocivité, j'ai beau chercher, toutes les études montrent un impact faible, et dans tous les cas inférieur à celui des autres pesticides, en particulier bio. https://t.co/uCZuYszcUa entre autre.
@MacLesggy @Remy2P Fabian Tomasi souffrait d'une neuropathie. "Le glyphosate ne présente ni neurotoxicité, ni cancérogénicité, ni toxicité pour la reproduction, ni teratogénicité, ni génotoxicité" selon la Commission japonaise de sécurité des aliments, septembre 2016. https://t.co/rU6v2isYnx
@MikeGabrielli1 @t4L @LauraLeaWatson1 @SciGroupie @BetteMidler @pcronald @BioBeef @mark_lynas Japan https://t.co/tyri19nfOj

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