著者
Kunihisa Miwa Masatoshi Fujita
出版者
The Japanese Society of Internal Medicine
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
vol.48, no.21, pp.1849-1854, 2009 (Released:2009-11-02)
参考文献数
18
被引用文献数
16 17

Objective Little attention has been paid to possible cardiovascular involvement in patients with chronic fatigue syndrome (CFS), although many of their symptoms and signs suggest cardiovascular dysfunction. Possible cardiovascular symptoms and cardiac function were investigated in CFS patients. Methods Cardiovascular symptoms were intensively investigated and cardiac function was evaluated echocardiographically. Patients Fifty-three patients (23 men and 30 women, mean age: 31±7 years) with CFS under 50 years were studied. Results Slender build (body mass index <20 kg/m2) was common (47%). Possible cardiovascular symptoms including shortness of breath (32%), dyspnea on effort (28%), rapid heartbeat (38%), chest pain (43%), fainting (43%), orthostatic dizziness (45%) and coldness of feet (42%), were all frequent complaints. Hypotension (28%) was occasionally noted. Electrocardiograms frequently revealed right axis deviation (21%) and severe sinus arrhythmia (34%) suggesting accentuated parasympathetic nervous activity. Small heart shadow (cardiothoracic ratio ≤42%) was noted on the chest roentgenogram in 32 patients (60%). Echocardiographic examination demonstrated low cardiac indexes (<2 L/min/m2) with low stroke volume indexes (<30 mL/m2) due to a small left ventricular chamber in 19 (36%, p<0.05 vs. 8% in 36 controls). None had reduced left ventricular ejection fraction. Conclusion Cardiovascular symptoms are common in CFS patients. Cardiac dysfunction with low cardiac output due to small left ventricular chamber may contribute to the development of chronic fatigue as a constitutional factor in a considerable number of CFS patients.

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外部データベース (DOI)

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@ohhjacqui @jakesuett @bmj_latest Calling them false negative cases assumes covid is the only cause. We do not know this. https://t.co/V61Fp4ayKb I note. I developed a disease with symptoms matching #longcovid after a trivial virus 1990. Around 1000 in the UK/3mo get #mecfs and will be mixed in with #longcovid.
@dysclinic Cardiac issues are quite common in #mecfs https://t.co/V61Fp4ayKb for one. It would be interesting to do detailed cardiac workups on #mecfs patients with non-covid onset and covid #longcovid patients.
@CardioOncology @NakedCapsid @davidrliu https://t.co/V61Fp4ayKb I note, along with CFS symptoms being similar to #longcovid . (30 years out from presumed viral infection triggering CFS and cardiac arrythmia)
@MBVanElzakker https://t.co/V61Fp4ayKb I sit here with sinus arrythmia and irregular heartbeat symptoms that occured at age 12 post a 'trivial'l virus that triggered/caused ME/CFS. My view is longcovid is likely symptoms specific to covid + triggered CFS state.
@trishgreenhalgh https://t.co/V61Fp4ayKb Is one of the papers showing heart issues in #mecfs. 'Echocardiographic examination demonstrated low cardiac indexes (<2 L/min/m2) with low stroke volume indexes (<30 mL/m2) due to a small left ventricular chamber in 19 (36%, p<0.05 vs. 8% in 36 controls)
@benjamesmorton @ISARIC1 @louise_sigfrid @UofGlasgow @JTSglobalhealth @WHO @fernando_bozza @gail_carson If you are picking up #longcovid symptoms after nonspecific viral illness, you are going to find some of those 400/day. https://t.co/V61Fp4ayKb #mecfs has a wide variety of symptoms. Answering if it's coincident or directly caused requires a SARS2 test or diagnosis.
@TomKindlon @mhornig @davidtuller1 I wonder if some of these cases are 'background' CFS/ME developing being assumed to be covid, as 'it can't be CFS/ME as that's trivial and just tiredness'. (developed tachycardia/MECFS after a trivial virus infection in 198?) https://t.co/V61Fp4ayKb several cardiac papers
@fascinatorfun covid - it doesn't seem unreasonable that it might trigger it too. #mecfs shares a _lot_ of the symptomology from fatigue to cardiac issues that #longcovid does. https://t.co/V61Fp4ayKb
@TomKindlon I would add sinus arrythmia and various heart dysfunction to the CFS pile. There are some pretty unique covid symptoms, covid toes/rash, and burning lungs. But a _lot_ shared. https://t.co/V61Fp4ayKb
@ClaireHastie1 @ellecalendula @TomKindlon There are coagulopathy driven problems - stroke/PE - but cardiac issues have been shown in CFS. https://t.co/V61Fp4ayKb https://t.co/gGUa7hszwE https://t.co/VLmdHsGXiP https://t.co/M4uuRd3xPf
@PHOSP_COVID @ScienceMagazine @jcouzin @dr_michaelmarks @ProfJDChalmers @REvans_Breathe @LouiseVwain I note that many of these symptoms, including cardiac issues, are found in most patients with CFS. https://t.co/V61Fp3SXlB https://t.co/gYF7Iw1N2H #mecfs #longcovid
With the attention paid to cardiac symptoms post-covid-19-acute phase, and the similarity of fatigue course to #mecfs in #longcovid I note this 2009 paper finding sinificant cardiac abnormality in #cfs https://t.co/V61Fp4ayKb #covid19 https://t.co/K1GMIyZDxZ

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