著者
Eikan Mishima Kazuichi Maruyama Toru Nakazawa Takaaki Abe Sadayoshi Ito
出版者
一般社団法人 日本内科学会
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
vol.56, no.13, pp.1687-1690, 2017-07-01 (Released:2017-07-01)
参考文献数
15
被引用文献数
2

CYP3A4-inhibitors can potentiate the hypotensive effect of calcium-channel blockers. However, insufficient attention to such drug interactions may result in serious adverse reactions. A 71-year-old hypertensive man prescribed nifedipine was hospitalized for infectious endophthalmitis. Antimicrobial therapy with voriconazole lowered the blood pressure, and then clarithromycin further lowered it through the excessively elevated nifedipine concentration, leading to ischemic acute kidney injury. After the discontinuation of clarithromycin and voriconazole, the blood pressure and renal function were recovered. The combination of CYP3A4-inhibitors such as clarithromycin plus voriconazole can synergistically potentiate calcium-channel blockers. Co-prescription of multiple CYP3A4-inhibitors with calcium-channel blockers increases the risk of hypotension and acute kidney injury.

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Acute Kidney Injury from Excessive Potentiation of Calcium-channel Blocker via Synergistic #CYP3A4 Inhibition by… https://t.co/0Clvcy975m
Interacción a considerar: Voriconazol + Claritromicina (sinergia CYP3A4) con Bloq Canales Ca https://t.co/0d9CYzRXn3 via @velezmeca
La interacción entre voriconazol/claritro + nifedipino puede ser peligrosa para el riñón https://t.co/XTG6fSKNP0 O… https://t.co/AuTUw8dbrh
[当科論文] Ca拮抗薬内服中の高血圧患者がCY3A4阻害薬(クラリスロマイシン+ボリコナゾール)の併用によって過降圧から急性腎障害を来した1例。三島先生の症例報告です Internal Medicine誌に掲載。https://t.co/zRySWIoygt

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