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61 0 0 0 OA A Case of New-onset Immune-mediated Necrotizing Myopathy and Trigeminal Neuropathy after SARS-CoV-2 mRNA Vaccination in a Patient with Rheumatoid Arthritis and Sjögren's Syndrome

著者
Takuma Tsuzuki Wada Kazuhiro Yokota Fumito Inayoshi Sakon Sakai Nobuhito Okumura Mayumi Matsuda Iichiro Osawa Yasuto Araki Yu Funakubo Asanuma Yuji Akiyama Toshihide Mimura
出版者
The Japanese Society of Internal Medicine
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
pp.2551-23, (Released:2023-10-13)
参考文献数
50
被引用文献数
3
We present the case of a 42-year-old woman with rheumatoid arthritis and Sjögren's syndrome treated with adalimumab who developed immune-mediated necrotizing myopathy (IMNM) and trigeminal neuropathy after SARS-CoV-2 mRNA vaccination. Trigeminal neuralgia and elevated serum creatine kinase levels emerged 12 days post-vaccination, followed by myalgia in the femoral muscles. IMNM was histologically diagnosed. The pathogenesis may involve molecular mimicry between the SARS-CoV-2 spike glycoprotein and autologous tissues triggered by vaccination. This case emphasizes the association between SARS-CoV-2 vaccination, tumor necrosis factor inhibitor, IMNM, and trigeminal neuropathy, as well as the importance of monitoring immune-mediated adverse events following SARS-CoV-2 vaccination in patients with autoimmune disease.

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外部データベース (DOI)

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Replace MILD with..PERSISTENT Pub 13 Oct 2023 "NEW-ONSET I.M. NECROTIZING MYOPATHY/TRIGEMINAL NEUROPATHY after S-CoV-2 mRNA Vaccination.." "42-yo woman,numbness,paresthesia,pain,28d after 3rd PFIZER,MYOFIBER NECROSIS" "PERSISTENT NEUROPATHY UNRESOLVED" https://t.co/kjDqKH3JuD https://t.co/1AFErjnX2d
5 @JodiWal79875206 @subhobrata1 @DravenS17 @db11770382
8 @db11770382 @DravenS17 @foofu @leedj150783 @MeasslainteIE @mike_morbius @shane73543472 @subhobrata1
A lire: myopathie nécrosante à médiation immunitaire et de neuropathie trijumeau après vax ARNm Cov , femme 42 ans atteinte polyarthrite rhumatoïde et du syndrome de Sjögren: https://t.co/mDCsXe4Eep https://t.co/rsUZ9ulYIr
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https://t.co/K0H5kkNVDQ
Pub 13 Oct 2023: "New-onset IM NECROTIZING MYOPATHY/TRIGEMINAL NEUROPATHY after S-COV-2 MRNA VACCINATION.." "42-yo woman,12d>3rd BNT162B2,TRIGEMINAL NEUROPATHY,MRI:ABNORMAL NON-NEOPLASTIC TRIGEMINAL NERVE,MYOFIBER NECROSIS" "NEUROPATHY remained UNRESOLVED" https://t.co/kjDqKH3JuD https://t.co/TVHuRwAWzz
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