著者
Tomoya Shintani Hirofumi Sakoguchi Akihide Yoshihara Ken Izumori Masashi Sato
出版者
The Japanese Society of Applied Glycoscience
雑誌
Journal of Applied Glycoscience (ISSN:13447882)
巻号頁・発行日
pp.jag.JAG-2019_0010, (Released:2019-10-24)
被引用文献数
1

D-Allose (D-All), C-3 epimer of D-glucose, is a rare sugar known to suppress reactive oxygen species generation and prevent hypertension. We previously reported that D-allulose, a structural isomer of D-All, prolongs the lifespan of the nematode Caenorhabditis elegans. Thus, D-All was predicted to affect longevity. In this study, we provide the first empirical evidence that D-All extends the lifespan of C. elegans. Lifespan assays revealed that a lifespan extension was induced by 28 mM D-All. In particular, a lifespan extension of 23.8% was achieved (p < 0.0001). We further revealed that the effects of D-All on lifespan were dependent on the insulin gene daf-16 and the longevity gene sir-2.1, indicating a distinct mechanism from those of other hexoses, such as D-allulose, with previously reported antiaging effects.

言及状況

外部データベース (DOI)

Twitter (1 users, 1 posts, 0 favorites)

Now available online on Journal of Applied Glycoscience- D-Allose, a stereoisomer of D-glucose, extends the lifespan of <i>Caenorhabditis elegans</i> via sirtuin and insulin signaling https://t.co/hC9YXgobJB

収集済み URL リスト