著者
Michio Shimabukuro Yoshimasa Hasegawa Moritake Higa Rie Amano Hirotsugu Yamada Shunsaku Mizushima Hiroaki Masuzaki Masataka Sata
出版者
Japan Atherosclerosis Society
雑誌
Journal of Atherosclerosis and Thrombosis (ISSN:13403478)
巻号頁・発行日
vol.22, no.8, pp.854-868, 2015-08-26 (Released:2015-08-26)
参考文献数
35
被引用文献数
10 6

Aim: The prevalence of overweight and a change in atherosclerotic lipid profiles may be linked to region-specific differences in atherosclerotic diseases. We evaluated whether the lipid phenotype could be linked to region- and sex-specific differences in the degree of atherosclerosis.Methods: Non-diabetic subjects included Okinawa (n=1674) and Nagano (n=1392) residents aged 30–75 years who underwent carotid ultrasonography for the measurement of maximum intima-media thickness (max IMT).Results: Average max IMT was higher in Okinawa men and women, and the increase in max IMT with age was enhanced in men. Multiple regression analysis showed that in addition to age and systolic blood pressure, low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol were IMT determinants only in men for both Okinawa and Nagano. Meanwhile, HDL-cholesterol was a determinant for Okinawa men and women, but not for Nagano men and women.Conclusions: This is the first report to show region- and sex-specific differences in the determinants for max IMT in a Japanese population. The evaluation of the relationship between lipid profile patterns and region- and sex-specific differences in carotid atherosclerosis burden may be required.

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@MigraineBook @EstebanDL @BenBikmanPhD Not sure I'd go that far, but they certainly are at increased risk of this b… https://t.co/AIqG9jkwQS
Paradoja Japonesa de enfermedad carotidea en mujeres LDL se relaciono con aumento de IMT en hombres pero no en muje… https://t.co/KIS710nSbu
@lansberg This unknown factor is no longer protecting the Okinawans offspring (currently middle aged): IR is now p… https://t.co/Rffn4t3iOw
@wyadvd @EAllen0417 @BBC_Future Clearly, middle aged Okinawans today are not doing as well as their parents. Cente… https://t.co/u7rgZxThkl

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