著者
Naoki Nago Shizukiyo Ishikawa Tadao Goto Kazunori Kayaba
出版者
日本疫学会
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
vol.21, no.1, pp.67-74, 2011-01-05 (Released:2011-01-05)
参考文献数
17
被引用文献数
24 43 23

Background: We investigated the relationship between low cholesterol and mortality and examined whether that relationship differs with respect to cause of death.Methods: A community-based prospective cohort study was conducted in 12 rural areas in Japan. The study subjects were 12 334 healthy adults aged 40 to 69 years who underwent a mass screening examination. Serum total cholesterol was measured by an enzymatic method. The outcome was total mortality, by sex and cause of death. Information regarding cause of death was obtained from death certificates, and the average follow-up period was 11.9 years.Results: As compared with a moderate cholesterol level (4.14–5.17 mmol/L), the age-adjusted hazard ratio (HR) of low cholesterol (<4.14 mmol/L) for mortality was 1.49 (95% confidence interval [CI]: 1.23–1.79) in men and 1.50 (1.10–2.04) in women. High cholesterol (≥6.21 mmol/L) was not a risk factor. This association was unchanged in analyses that excluded deaths due to liver disease, which yielded age-adjusted HRs of 1.38 (95% CI, 1.13–1.67) in men and 1.49 (1.09–2.04) in women. The multivariate-adjusted HRs and 95% CIs of the lowest cholesterol group for hemorrhagic stroke, heart failure (excluding myocardial infarction), and cancer mortality significantly higher than those of the moderate cholesterol group, for each cause of death.Conclusions: Low cholesterol was related to high mortality even after excluding deaths due to liver disease from the analysis. High cholesterol was not a risk factor for mortality.

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低コレステロールは脳血管障害、心疾患、ガンによる死亡と関係がある。高コレステロール自体は死亡リスクではない。 自治医科大学のコホート研究による https://www.jstage.jst.go.jp/article/jea/21/1/21_JE20100065/_pdf 2012年9月のパネルディスカッション「再考コレステロール問題」(第21回大会・麻布大学)(YouTubeビデオ) http: ...
Düşük Kolesterol Ölüm Riskini Artırıyor Kolesterol yüksekliğinin genel olarak çok tehlikeli olduğu ve ölüm riskini artırdığı kabul edilir ama kolesterol düşüklüğünün riskleri hakkında çok fazla bilg ...
Merhaba Arkadaşlar, Önemli bence. Herkese duyuralım. Kolay Gelsin... Düşük kolesterol ölüm riskini artırıyor Kolesterol yüksekliğinin genel olarak çok tehlikeli olduğu ve ölüm riskini artırdığı kabu ...
Merhaba Arkadaşlar, Önemli bence. Herkese duyuralım. Kolay Gelsin... Düşük kolesterol ölüm riskini artırıyor Kolesterol yüksekliğinin genel olarak çok tehlikeli olduğu ve ölüm riskini artırdığı kabu ...
Merhaba Arkadaşlar, Önemli bence. Herkese duyuralım. Kolay Gelsin... Düşük kolesterol ölüm riskini artırıyor Kolesterol yüksekliğinin genel olarak çok tehlikeli olduğu ve ölüm riskini artırdığı kabu ...
The Dangers of Low Cholesterol June 1, 2011 A female client of mine told me the other day that her doctor wants to put her on a statin drug to lower her cholesterol. “My count is over 200,” she ex ...

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J Epidemiol 2011;21(1):67-74 Low Cholesterol Asso w/ Mortality From Stroke, Heart Disease & Cancer: http://t.co/jrwLq4BD2n
Düşük Kolesterol Ölüm Riskini Artırıyor Kolesterol yüksekliğinin genel olarak çok tehlikeli olduğu ve ölüm... http://t.co/BpdJRVu6O7

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