著者
Naoki Nago Shizukiyo Ishikawa Tadao Goto Kazunori Kayaba
出版者
Japan Epidemiological Association
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
pp.1012070204-1012070204, (Released:2010-12-11)
参考文献数
17
被引用文献数
28 66

Background: We investigated the relationship between low cholesterol and mortality and examined whether that relationship differs with respect to cause of death.Methods: A community-based prospective cohort study was conducted in 12 rural areas in Japan. The study subjects were 12 334 healthy adults aged 40 to 69 years who underwent a mass screening examination. Serum total cholesterol was measured by an enzymatic method. The outcome was total mortality, by sex and cause of death. Information regarding cause of death was obtained from death certificates, and the average follow-up period was 11.9 years.Results: As compared with a moderate cholesterol level (4.14–5.17 mmol/L), the age-adjusted hazard ratio (HR) of low cholesterol (<4.14 mmol/L) for mortality was 1.49 (95% confidence interval [CI]: 1.23–1.79) in men and 1.50 (1.10–2.04) in women. High cholesterol (≥6.21 mmol/L) was not a risk factor. This association was unchanged in analyses that excluded deaths due to liver disease, which yielded age-adjusted HRs of 1.38 (95% CI, 1.13–1.67) in men and 1.49 (1.09–2.04) in women. The multivariate-adjusted HRs and 95% CIs of the lowest cholesterol group for hemorrhagic stroke, heart failure (excluding myocardial infarction), and cancer mortality significantly higher than those of the moderate cholesterol group, for each cause of death.Conclusions: Low cholesterol was related to high mortality even after excluding deaths due to liver disease from the analysis. High cholesterol was not a risk factor for mortality.

言及状況

外部データベース (DOI)

はてなブックマーク (2 users, 2 posts)

高コレステロールはむしろリスクになっていないという結果 RT @bycomet: 低コレステロールで死亡率1.5倍!日本人のコホート研究発表 / JEA
低コレステロールで死亡率1.5倍!日本人のコホート研究発表

Twitter (159 users, 161 posts, 614 favorites)

@BadassDalit @shashiiyengar @dlifein We don't need to check our lipids you need to check more research papers. 1.https://t.co/W8uMNf8yS3 https://t.co/Zn7Mvr0pe0 2.https://t.co/6xnNEmqw5H 3.https://t.co/RuFhMlmQUd 4.https://t.co/jdkcVoOy39 https://t.co/oWIDaWbuzM
@ElsenKristof @SBakerMD What sort of blood work looks "bad", higher LDL? https://t.co/tzWvyWBwiE
Low Cholesterol Associated With Mortality From Stroke, Heart Disease,Cancer —Age-adjusted HR of low cholesterol (<4.14 mmol/L) for mortality HR=1.49 in men & HR=1.50 in women vs moderate level (4.14–5.17) —High cholesterol (≥6.21 mmol/L) not a risk factor https://t.co/HLuoa9HADY
@Stary529 Ja tomu samozřejmě rozumím. Ono to dle všech možných studií s tím samotným LDL, jako příčinou kardiovaskulárních onemocnění, je opravdu jinak. Vysoký LDL neznamena automaticky špatně, ba spíš naopak. Napr. https://t.co/dRkAXsLJJW
@Chandle74418127 @dobierun @Mangan150 Another https://t.co/EEnZntGSlW
Η χαμηλή χοληστερίνη σχετίζεται με θνησιμότητα από εγκεφαλικό επεισόδιο, καρδιακές παθήσεις και καρκίνο. Άνδρες με χαμηλή χοληστερίνη, <150, είχαν 1,5 φορές μεγαλύτερο ποσοστό θνησιμότητας από εκείνους με φυσιολογική χοληστερόλη. Αυτό είναι όλο. #Health https://t.co/YNSbVjLDeB
Journal of Epidemiology- Low Cholesterol is Associated With Mortality From Stroke, Heart Disease, and Cancer: The Jichi Medical School Cohort Study "High cholesterol was not a risk factor for mortality'. https://t.co/Bn5AxnwfTn
Low Cholesterol is Associated With Mortality From Stroke, Heart Disease, and Cancer: The Jichi Medical School Cohort Study @tha https://t.co/v4iDXNXhyD
Low Cholesterol is Associated With Mortality From Stroke, Heart Disease, and Cancer Men with low cholesterol, <150, had 1.5 times the death rate as those with normal cholesterol. High cholesterol was not a risk factor. That is all. https://t.co/2KusjWOCdS
" Low #cholesterol was related to high #mortality even after excluding deaths due to liver disease from the analysis. High cholesterol was not a risk factor for mortality. " Whew wonder how they got there! #Japan must be #special! Nago et al 2011 https://t.co/kTfDnSTrqt

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