著者
奥山 治美
出版者
日本環境変異原学会
雑誌
環境変異原研究 (ISSN:09100865)
巻号頁・発行日
vol.25, no.2, pp.147-157, 2003 (Released:2005-08-19)
参考文献数
87
被引用文献数
2 3

Substances causing persistent inflammation (asbestos, viruses and pathogens) are often carcinogenic even if they are not directly mutagenic. Reactive oxygen species from inflammatory cells injure DNA and are cell-proliferative leading to accelerated carcinogenesis. Lipid mediators in the linoleic acid (LA) cascade through arachidonic acid (n-6) and some cytokines form amplification cascades to stimulate these processes, whereas the fatty acids of n-3 type competitively suppress the LA cascade and carcinogenesis. This interpretation is consistent with the observations that (1) dietary oils with low n-6/n-3 ratios are suppressive compared with high-LA oils, (2) inhibitors of the LA cascade are suppressive, and (3) manipulations to knockout genes related to the LA cascade are suppressive for carcinogenesis. On the other hand, many kinds of genes are affected differently by the chain length and unsaturation of fatty acids regardless of the n-6 or n-3 type. Saturates, monounsaturates and LA up-regulate cholesterol synthesis leading to enhanced prenylation of oncogene products, cell-proliferation and carcinogenesis. Dietary cholesterol and high tissue cholesterol levels feedback suppress cholesterol synthesis and cell-proliferative stimuli, which partly accounts for epidemiological observations that cancer mortality is lower in the group with higher cholesterol level. For the cancers, the incidence of which is high in the US and has been increasing rapidly in Japan, reducing the intake of LA to half while maintaining those of n-3 fatty acids and animal fats at the levels of average Japanese is recommended.

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外部データベース (DOI)

Twitter (19 users, 22 posts, 97 favorites)

https://t.co/7N7Vk5oAhg 重要なことなので、再度貼り付けます。 単なる脂質制限ではなく、摂取脂質の割合(オメガ3/6比)を考えることの方が正しいと思います。
今夜の睡眠はコレで決まりッ 名古屋市立大学薬学研究科 https://t.co/WZOby43esq #リノール酸リッチと炎症 https://t.co/zle74wu8T0
https://t.co/7N7Vk5oAhg はい注目!
あとはαリノレン酸(n-3系)の摂取は「乳がん」などの発癌抑制に繋がると言ってもよさそうです。 https://t.co/ZQCSOfKVcT https://t.co/OCQwDMtox5
・リノール酸の1日の必須量はわずか2g ・癌は高リノール酸の植物油(オメガ6系)の植物油で促進され、αリノレン酸(オメガ3系油脂)により抑制される リノール酸の摂り過ぎによる炎症性疾患としての癌/#奥山治美 https://t.co/foIA9LUqEV https://t.co/OQqh6NbAIg
@inunoshanpu_ya リノール酸は炎症を促進するしねー( ´•ω•` ) これめっちゃ面白かった! https://t.co/dL7VRDRUeM

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