著者
妹尾 春樹
出版者
日本食生活学会
雑誌
日本食生活学会誌 (ISSN:13469770)
巻号頁・発行日
vol.18, no.4, pp.309-316, 2008-03-30 (Released:2008-05-09)
参考文献数
37

Nobu Shirase (born in Konoura in Akita Prefecture) was a pioneer of polar expedition. He reached 80° 5' south latitude in 1912 after Amundsen and Scott reached the South Pole. White bear (polar bear) is a unique animal in the Arctic, and stores a large amount of vitamin A in the liver. Hepatic stellate cells (vitamin A-storing cells, lipocytes, interstitial cells, fat-storing cells, Ito cells) exist in the space between parenchymal cells and sinusoidal endothelial cells of the hepatic lobule, and store 80 % of vitamin A in the whole body as retinyl palmitate in lipid droplets in the cytoplasm in mammals such as human or rats. In physiological conditions, these cells play pivotal roles in the regulation of vitamin A homeostasis; they express specific receptors for retinolbinding protein (RBP), a binding protein specific for retinol, on their cell surface, and take up the complex of retinol and RBP by receptormediated endocytosis. Hepatic stellate cells in top predators in arctic animals such as polar bears and arctic foxes store 20-100 times the levels of vitamin A found in human or rat. Nuclear deviation in hepatic parenchymal cells, degeneration of Glisson's sheath, inflammation of the intestine, and a shift of vitamin A-storing site from the liver to the kidney were found in the arctic top predators. These findings were not reported in the wild animals and alarming to the human beings.

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シロクマから人への警告(PDF) 為になるわ... https://t.co/OHaPmpEjCu https://t.co/QQxUartnwg
シロクマから人への警告 北極圏におけるビタミンA貯蔵細胞の研究から https://t.co/qs4hXgtD2t https://t.co/71yPQqMKtr
@yamasakusen ヒゲアザラシやシロカモメの肝臓もビタミンAが多いみたいだからくれぐれも気をつけて。 気になったので知恵袋先生ではなく真面目に調べました。 https://t.co/leKL9dG0av
【第一回 クマレポ】 参考文献 妹尾 春樹『シロクマからヒトへの警告 -北極圏におけるビタミンA貯蔵細胞の研究から-』 https://t.co/0TdHkprGt6
【メモ】研究論文: シロクマからヒトへの警告 https://t.co/MEejDMJRCN

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