著者
伊藤 耕三
出版者
The Japanese Society for Hygiene
雑誌
日本衛生学雑誌 (ISSN:00215082)
巻号頁・発行日
vol.26, no.3, pp.304-314, 1971-08-28 (Released:2009-02-17)
参考文献数
40
被引用文献数
8 14

Nitrogen dioxide is one of the main atmospheric pollutants in many communities. It is emitted in large quantities in the exhaust of automotive engines and is formed when atmospheric nitrogen and oxygen are heated to a high temperature in a flame.Experiments were made to ascertain possible synergistic effects of nitrogen dioxide and influenza virus infection in mice. Young female dd strain mice weighing 15 to 17g were challenged with mouse-adapted type A influenza virus, strain PR 8, two hours after acute and intermittent exposure to 10ppm nitrogen dioxide for two hours daily for one, three and five days. Female I.C.R. strain mice weighing 22 to 25g were also challenged with type A influenza virus after continuous exposure to 0.5 to 1.0ppm nitrogen dioxide for 39 days.Results were as follows;1) Acute and intermittent exposure to 10ppm nitrogen dioxide for two hours daily for five days significantly increased the susceptibility of mice to influenza virus infection as demonstrated by enhanced mortality.2) Extent of interstitial pneumonia was higher in the mice challenged with influenza virus after chronic and continuous exposure and acute and intermittent exposure to nitrogen dioxide than in the infected controls.3) Adenomatous proliferations of bronchial and bronchiolar epithelium were marked in the mice challenged with influenza virus after continuous exposure to low levels of nitrogen dioxide.

言及状況

外部データベース (DOI)

Twitter (2 users, 2 posts, 0 favorites)

中国人に劇症化が起こる理由はこの辺かなぁ NO2ガス暴露がマウスのインフルエンザウィルス感染に及ぼす影響 https://t.co/LBf8EYv8gd 亜硫酸ガスと気道ウイルス感染 https://t.co/Y8cZZGz6ZR

収集済み URL リスト