著者

齊藤 昌樹 畑中 隆志 川口 拓郎 久馬 孝仁 長嶺 健二郎 澤木 佳弘

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.61, no.12, pp.667-672, 2015-12-20 (Released:2016-03-14)

参考文献数

34

被引用文献数

1 5

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Recently, methotrexate-associated lymphoproliferative disorders (MTX-LPD) in patients with rheumatoid arthritis (RA) have frequently been reported as a lymphoproliferative disorder developing in immunosuppressed patients. Many reports have indicated a relation between MTX-LPD and Epstein-Barr virus (EBV). We report 4 cases of EBV-positive MTX-LPD arising in the oral cavity. After consulting a hematologist, methotrexate (MTX) was discontinued in three patients, and one patient moved to another medical facility. Three lesions regressed after MTX withdrawal. However, one patient who resumed treatment with MTX had a relapse of LPD. A literature search on MTX-LPD in the oral cavity revealed a high positive rate of EBV, a good response to MTX withdrawal, a higher prevalence in women, and a high frequency of maxillary gum involvement.