著者
五郎丸 剛 佐々木 智也 藤井 利加 一木 孝治 高橋 浩二郎 福長 将仁 江藤 精二
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.34, no.1, pp.59-63, 2008 (Released:2009-09-04)
参考文献数
16
被引用文献数
1 1

Antibiotic-resistant lactic acid bacteria (RLAB) and clostridium butyricum (CB) preparations are often used to improve symptoms resulting from antibiotic-induced changes in intestinal flora.However,though the resistance of these preparations to fluoroquinolones (FQs) has not been sufficiently studied,they are sometimes prescribed in combination with FQs under off-label use.The reason for this is thought to be that all RLAB and CB preparations are considered to be resistant to all antibiotic agents.In this study,we determined the minimal inhibitory concentrations of FQs with respect to strains isolated from five RLAB and one CB preparation using the microdilution method.Furthermore,the susceptibility to FQs of the strains isolated from the RLAB preparations was compared with that of strains isolated from conventional lactic acid preparations.The strains from most of the RLAB preparations and that from the CB preparation were found to be susceptible to FQs.There was also no difference in bacterial resistance between the RLAB and conventional lactic acid preparations.The concurrent use of RLAB and FQs under off-label use should therefore be avoided.

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@mg_pharmacist フルオロキノロン系抗菌剤に対する耐性乳酸菌および酪酸菌製剤の感受性について https://t.co/28VAfimZI9 FQsは、乳酸菌、耐性乳酸菌、発芽した酪酸菌に対して感受性を示す(各種菌は耐性を獲得できない)。 酪酸菌は芽胞形成時は安定だが、小腸に到達して増殖する際には発芽する。
@totsuration どうでもいいけど参考文献に五郎丸姓の方がいてビックリした https://t.co/cO6b2DUJdg
ミ○BMとビ○フェル○ンはどちらが良いのかな?有意差は無いと思っています。https://t.co/NQsX5Ahyz0

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