著者
渡邊 美智留 三田 恭平 中村 春世 田中 恒明 三原 潔 小野 秀樹
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.40, no.12, pp.726-733, 2014-12-10 (Released:2015-12-10)
参考文献数
9

Pregabalin, a useful drug for neuropathic pain, has a high incidence of dizziness and somnolence as side effects. In the present study, the incidence of both side effects and the risk factors were retrospectively investigated in hospitalized patients who were administered pregabalin after their admission. In 65 patients (median 68 years old), 34 cancer patients and 18 opioid users were included. Items studied were cancer/non-cancer, opioid user/non-user, fall/nonfall, age, sex, weight, daily dose of opioids, the number of the drugs that may cause dizziness and somnolence, daily dose of pregabalin, and the ratio of creatinine clearance to daily dose of pregabalin. Fourteen (21.5%) and 21 (23.3%) patients developed dizziness and somnolence, respectively, and 4 (6.1%) patients developed fall. In the case of opioid combination, 7 (38.9%) and 10 (55.6%) patients developed dizziness and somnolence, respectively. A logistic-regression analysis showed that opioid use is a significant augmenting risk factor for dizziness (P = 0.026) and somnolence (P = 0.016) of pregabalin. The ratios of daily dose of pregabalin to creatinine clearance did not show any relation to the incidence of dizziness and somnolence; both side effects were observed in some patients whose renal functions were normal. It is suggested that attention is necessary to the incidence of dizziness and somnolence regardless of renal function, and that particular attention is required when opioids, which have similar side effects, are combined with pregabalin.

言及状況

外部データベース (DOI)

Twitter (6 users, 7 posts, 9 favorites)

傾眠の原因が判った。 セレコキシブとプレガバリンの併用だろうと思う 論文 https://t.co/K9tlF7QHRC
#プレガバリン トラマドール の副作用に対する漢方治療 (特集 #末梢神経障害 を緩和するために) -- (さまざまな #神経障害性疼痛 ) https://t.co/bCUgnbpHyh #プレガバリン 投与後に発現する #めまい および #傾眠 のリスク因子の検討 https://t.co/9qJJhvMtrp https://t.co/87J5u3fEr7

収集済み URL リスト