著者
大荒田 素子 宮沢 陽夫
出版者
Japan Oil Chemists' Society
雑誌
油化学 (ISSN:18842003)
巻号頁・発行日
vol.39, no.6, pp.373-379, 1990-06-20 (Released:2009-10-16)
参考文献数
40
被引用文献数
4 5

Among the oxidation products of edible fats and oils, lipid hydroperoxides and the low-molecular-weight compounds containing short-chain aldehydes such as 4-hydroxynonenal are absorbed from the intestinal wall and carried into the internal organs with oral administration to rodents. Oral intake of lipid hydroperoxides or the low-molecular-weight compounds causes significant cytotoxic damage to the lymphoid tissues. The DNA synthesis of thymocytes is remarkably depressed and lymphocyte necrosis is observed in the thymus and intestinal Peyer's patches. In these cases, the mitogenic response to concanavalin A of splenocytes is increased. With long-term (90 d) feeding of slightly autoxidized soybean oil (peroxide value ; 150 meq/kg) in mice, the same symptoms as those mentioned above are observed. These findings indicate that oral intake of rancid oils give significant effects on immunocompetent cells and causes depression of the DNA synthesis of thymocytes, which would be one of the major cause for impairing immunocompetent systems in animals.

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