著者

Hiroaki Eshima

出版者

The Japanese Society of Physical Fitness and Sports Medicine

雑誌

The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)

巻号頁・発行日

vol.9, no.5, pp.199-204, 2020-09-25 (Released:2020-09-16)

参考文献数

42

被引用文献数

2

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Obesity and aging reduce skeletal muscle contractile function, which represents a reduction in muscle quality. Dysfunction of muscle contraction may contribute to a greater risk for diabetes, cardiovascular diseases, and cancer; therefore, the synergistic effects of obesity and aging on muscle function may exacerbate morbidity and mortality. However, evidence directly examining the synergistic effects of obesity and aging on muscle contractile function is lacking and controversial. We recently demonstrated that diet-induced obesity significantly exacerbates contractile dysfunction in aged skeletal muscle. The focus of this review is the effects of obesity on muscle contractile dysfunction in skeletal muscle, particularly during aging.