著者
Hiroyuki Nakamura Toshihiko Murayama
出版者
The Japanese Pharmacological Society
雑誌
Journal of Pharmacological Sciences (ISSN:13478613)
巻号頁・発行日
vol.124, no.3, pp.307-312, 2014-03-20 (Released:2014-03-18)
参考文献数
30
被引用文献数
27 30

The arachidonic acid (AA) cascade is regulated mainly by the actions of two rate-limiting enzymes, phospholipase A2 (PLA2) and inducible cyclooxygenase-2 (COX-2). PLA2 acts to generate AA, which serves as the precursor substrate for COX-2 in the metabolic pathway leading to prostaglandin production. Amongst more than 30 members of the PLA2 family, cytosolic PLA2α (cPLA2α, group IVA) plays a major role in releasing AA from cellular membranes. Sphingolipids are a novel class of bioactive lipids that play key roles in the regulation of several cellular processes including growth, differentiation, inflammatory responses, and apoptosis. Recent studies implicated a regulatory function of sphingolipids in prostaglandin production. Whereas ceramide-1-phosphate and lactosylceramide activate cPLA2α directly, sphingosine-1-phosphate induces COX-2 expression. Sphingomyelin has been shown to inhibit the activity of cPLA2α. In addition, several sphingolipid analogs including a therapeutic agent currently used clinically are also reported to be inhibitors of cPLA2α. This review explores the role of sphingolipids in the regulation of cPLA2α and COX-2.

言及状況

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@ENirenberg @ImmunoFever @stephanielangel @AndreyKruglov6 @GuthmillerJenna Cullis patent (1) on a hydrogenated sphingomyelin might be the closest SM-102 characterization I can provide. Sphingomyelin does have an effect on sIgA. (2) Further, it regulates PLA2. (3) 1.) https://t.co/6S62Y0phn6 2.) https://t.co/pf4i4hYRX5 3.) https://t.co/tobHp5o2di

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