著者

小木曽 太郎

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.61, no.3, pp.119-127, 2001 (Released:2019-05-18)

参考文献数

35

被引用文献数

1

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Delivery of drugs via the skin has many attractions, including avoidance of gastro-intestinal disturbance and first-path metabolism, long-term maintenance of therapeutic plasma concentration and increased patient acceptability. This paper discusses the factors influencing the percutaneous absorption of drugs: lipophilicity, molecular size, melting point, cutaneous metabolism and skin binding of drugs. Additionally, quantitative structure-permeability relationships (QSPR) for skin penetration were discussed based on the octanol-water partition coefficient, molecular weight and electronic charge of drugs. Nonirritant enhancement methods, such as use of nonirritant penetration enhancers and formation of a complex or an ion pair, for drug penetration through skin were also described. As a result, the suitability of a drug for transdermal drug delivery was proposed.