著者

Hideaki Yamamoto Ayumi Hirano-Iwata Shigeo Sato

出版者

The Japan Society of Applied Physics

雑誌

JSAP Review (ISSN:24370061)

巻号頁・発行日

vol.2023, pp.230420, 2023 (Released:2023-07-06)

参考文献数

18

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The structure and function of complex neuronal networks in the brain can be partially reconstituted in vitro by integrating cell culture and microfluidic device technologies. In this report, we review our recent studies on developing microfluidic devices to reconstitute small neuronal networks bearing a modular structure, which is a canonical structure found in the nervous systems of animals. We also describe the process of recording functional activity from the reconstituted neuronal networks. These fundamental technologies offer novel tools for investigating structure–function relationships in living neuronal networks and exploring the physical basis of biological computing in the brain.