著者
矢船 明史 津谷 喜一郎
出版者
日本臨床薬理学会
雑誌
臨床薬理 (ISSN:03881601)
巻号頁・発行日
vol.27, no.3, pp.635-645, 1996-09-30 (Released:2010-06-28)
参考文献数
55
被引用文献数
4 or 2

There has been an increasing number of clinical reports in the West to suggest that hepatotoxic reactions can be induced by herbal preparations including skullcap of Scutellaria species. In Japan, the root of Scutellaria baicalensis (Scutellariae Radix) is used under the name of Ogon, which is included in many kinds of Kampo formulations, such as Sho-saiko-to widely used for treating hepatic disorders. Reviewing the Information on Adverse Reactions to Drugs published by the Ministry of Health and Welfare of Japan, we found 22 cases of liver and biliary system reactions caused by Kampo formulations from 1989 through 1993, and in 20 of the cases, six types of Kampo formulations including Ogon were suspected as the cause of the reactions. In two clinical reports of pulmonary damage due to Sho-saiko-to, Lymphocyte Stimulation Test indicated that Ogon was the causative factor for the damage. Although there have been no reports to indicate that Ogon can actually cause liver damage, the results of our review strongly suggest the necessity for surveillance of the possibility of hepatotoxic reactions caused by Ogon.

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【臨床薬理 27(3) 635-645,1996】 Scutellaria属の生薬による肝障害ならびに同属のオウゴン含有漢方処方による肝機能障害について https://t.co/S5bKEdqRlP https://t.co/1B1U77ghol
【臨床薬理 27(3) 635-645,1996】 Scutellaria属の生薬による肝障害ならびに同属のオウゴン含有漢方処方による肝機能障害について https://t.co/S5bKEdqRlP https://t.co/1B1U77ghol
Scutellaria属の生薬による肝障害ならびに同属のオウゴン含有漢方処方による肝機能障害について https://t.co/Ae5pWZEjCb

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