著者
武田 憲昭
出版者
Japan Society for Equilibrium Research
雑誌
Equilibrium Research (ISSN:03855716)
巻号頁・発行日
vol.59, no.2, pp.93-102, 2000 (Released:2009-06-05)
参考文献数
53
被引用文献数
3

In the acute period, the goal of drug therapy for vertigo is suppressing the sensation of vertigo, preventing vomiting and helping restore normal balance. Intravenous injection of NaHCO3 is effective against the sensation of vertigo. Since histamine H1-receptors are involved in vomiting that is associated with vertigo, antihistamines could prevent it. Benzodiazepines may restore normal balance by stimulating the initial develop-ment of vestibular compensation, in addition to their antianxiety effects. In the chronic period, vasodilators such as diphenidol or betahistine could prevent recurrent attacks of vertigo. Benzodiazepines may act on the limbic system and relieve psychotic triggering of vertigo attacks. Meniere's disease, in which the primary pathology is endolymphatic hydrops, is specifically managed by an osmotic diuretic, isosorbide. Steroids may be helpful in patients with vestibular neuronitis.

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少し古い総説ですがそれによれば、アタP(H1ブロッカー)は嘔吐中枢に作用して、前庭性の悪心・嘔吐を特異的に抑制するそうです。一方D2ブロッカーであるプリンペランは前庭性の嘔吐を直接的には抑制しないそうです(間接的には効果はあります)。 https://t.co/mCWEBCgYLx https://t.co/DWe99FFxe3

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