著者

祝迫 惠子 坂口 志文

出版者

一般社団法人 日本移植学会

雑誌

移植 (ISSN:05787947)

巻号頁・発行日

vol.52, no.6, pp.483-488, 2017 (Released:2018-02-14)

参考文献数

19

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Organ transplantation remains the only fundamental treatment for end-stage organ failure. Immunosuppression therapy is the key to successful post-transplantation outcomes. Although the survival after organ transplantation has improved with the development of immunosuppressant, chronic rejection and side effects of long-term exposure to immunosuppression remain ongoing concerns. Immune tolerance is important for normal physiology, and occurs in two forms: central and peripheral. The regulatory T cell is the essential constituent in peripheral tolerance. Regulatory T cells specialize in suppressing immune responses, including autoimmune disease, allergy or alloreaction. Regulatory T-cell therapy in transplantation may be emerging as an alternative therapeutic choice.