著者
Asuka Kaizaki Sachiko Tanaka Satoshi Numazawa
出版者
日本毒性学会
雑誌
The Journal of Toxicological Sciences (ISSN:03881350)
巻号頁・発行日
vol.39, no.1, pp.1-6, 2014-02-01 (Released:2014-01-10)
参考文献数
23
被引用文献数
19 54

1-phenyl-2-(1-pyrrolidinyl)-1-pentanone (α-PVP) is a new designer drug of the cathinone type. People who have taken drugs containing α-PVP or other synthetic cathinone reportedly lose consciousness, develop difficulty breathing, and at worst case, die. However, the mechanism underlying α-PVP-induced neurotoxicity is unknown. The objective of the present study was to investigate the effect of α-PVP on the central nervous system (CNS) and compare its neurotoxicity with that of methamphetamine (METH) in mice. Balb/c male mice (8 weeks old) were orally administered α-PVP (25 mg/kg) or METH (5 mg/kg). α-PVP induced a significant increase in locomotor activity, which occurred earlier than locomotor activity induced by METH. This increase was inhibited by the D1 receptor antagonist SCH23990 (50 µg/kg, i.p.) and the D2 receptor antagonist sulpiride (50 mg/kg, i.m.). The extracellular concentration of dopamine (DA) in the striatum, determined by in vivo microdialysis increased immediately after α-PVP administration. These results suggest that α-PVP stimulates DA release, causing an increase in locomotor activity, and that this stimulatory effect of α-PVP on CNS is mediated, at least in part, by the D1 and D2 receptors.

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New article on #alphaPVP #CNS #activation in The Journal of Toxicological Sciences https://t.co/6nFLlMv2Io
#αPVP appears to stimulate DA release and mediates its effects, at least in part, by the D1 and D2 receptors http://t.co/4cPQaOJfjY

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