著者
Hakimullah HAKIM Chanathip THAMMAKARN Atsushi SUGURO Yuki ISHIDA Akinobu KAWAMURA Miho TAMURA Keisuke SATOH Misato TSUJIMURA Tomomi HASEGAWA Kazuaki TAKEHARA
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
vol.77, no.2, pp.211-215, 2015 (Released:2015-03-01)
参考文献数
32
被引用文献数
14 18

Hypochlorous acid (HOCl) solutions were evaluated for their virucidal ability against a low pathogenic avian influenza virus (AIV), H7N1. HOCl solutions containing 50, 100 and 200 ppm chlorine (pH 6) or their sprayed solutions (harvested in dishes placed at 1 or 30 cm distance between the spray nozzle and dish) were mixed with the virus with or without organic materials (5% fetal bovine serum: FBS). Under plain diluent conditions (without FBS), harvested solutions of HOCl after spraying could decrease the AIV titer by more than 1,000 times, to an undetectable level (< 2.5 log10TCID50/ml) within 5 sec, with the exception of the 50 ppm solution harvested after spraying at the distance of 30 cm. Under the dirty conditions (in the presence of 5% FBS), they lost their virucidal activity. When HOCl solutions were sprayed directly on the virus on rayon sheets for 10 sec, the solutions of 100 and 200 ppm could inactivate AIV immediately after spraying, while 50 ppm solution required at least 3 min of contact time. In the indirect spray form, after 10 sec of spraying, the lids of the dishes were opened to expose the virus on rayon sheets to HOCl. In this form, the 200 ppm solution inactivated AIV within 10 min of contact, while 50 and 100 ppm could not inactivate it. These data suggest that HOCl can be used in spray form to inactivate AIV at the farm level.

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外部データベース (DOI)

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@h_okumura リンク先の論文に、50ppmの濃度の次亜塩素酸水を30センチの距離でスプレーしても効果は見られないという結果があるようですが、50ppm程度の次亜塩素酸水を噴霧しても無意味だと思うのです。(間違っていたらごめんなさい) https://t.co/gPyXnvRj6S
@akizukid 英語分からんけど、ようつべで紹介されてた5年前の日本獣医学会誌の論文。噴霧で使われる50ppmの濃度だと、30センチ離してスプレーしたら効果なかったっぽい。 https://t.co/gPyXnvRj6S
空間除菌でやってる次亜塩素酸水の噴霧って濃度50ppmくらいだし、スプレーで効果ないならミストは尚更? J-STAGE Articles - Evaluation of sprayed hypochlorous acid solutions for their virucidal activity against avian influenza virus through in vitro experiments https://t.co/c0gWVHzlDe
Evaluation of sprayed hypochlorous acid solutions for their virucidal activity against avian influenza virus through in vitro experiments https://t.co/c0gWVHzlDe 50ppmの次亜塩素酸水を30cm離してスプレーしても鳥インフルエンザウイルスを不活性化できなかった… これって噴霧は…
Hakim, Hakimullah, et al. "Evaluation of sprayed hypochlorous acid solutions for their virucidal activity against avian influenza virus through in vitro experiments." Journal of Veterinary Medical Science (2014): 14-0413. https://t.co/XgG8NcC5s3 空間は難しそう https://t.co/wOBKvhdRFO
@PalliThordarson A question for the chemists: what's mechanism & effectiveness of hypochlorous acid (HOCl) to neutralize viruses? Papers like this describe the effect https://t.co/T7GM4XWaAQ & https://t.co/uq7bAiEdGq. How does it compare to bleach (NaOCl)? It's been too many years since orgo!

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