著者
Sachiko HYOKAI Hiroyo TANAKA Noriyuki AIHARA Junichi KAMIIE
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.20-0718, (Released:2021-01-29)

In canine lymphoma, drug resistance is the major factor hindering treatment. In this study, we performed immunohistochemical examination of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), which are considered as transporters related to multidrug resistance in three recurrent canine lymphomas. All cases were negative for both transporters before anticancer drug administration, but became positive after this administration. The expression was confirmed in capillary endothelial cells, such as in brain capillaries acting as the blood-brain barrier (BBB). It is suggested that both transporters expressed on capillary endothelial cells in lymphoma tissue may inhibit the spread of anticancer drugs into tumor tissues from blood, the same as the BBB. Therefore, capillary endothelial cells could act as a blood-tumor barrier, which might be involved in drug resistance in canine lymphoma.

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Expression of P-glycoprotein and breast cancer resistance protein in three cases of canine lymphoma showing drug resistance. https://t.co/F7K8Z7uzKm
Expression of P-glycoprotein and breast cancer resistance protein in three cases of canine lymphoma showing drug resistance. https://t.co/4Lak4oUJ93
expression of P-glycoprotein&breast cancer resistance protein in 3 cases of canine #lymphoma showing drug resistance. It is suggested that transporters expressed on capillary endothelial cells may inhibit the spread of anticancer drugs into tumor tissues https://t.co/Z0mfUcqRSI https://t.co/uNsWy3wj8M

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