著者
Koji Kanamori Noriko Ihana-Sugiyama Ritsuko Yamamoto-Honda Tomoka Nakamura Chie Sobe Shigemi Kamiya Miyako Kishimoto Hiroshi Kajio Kimiko Kawano Mitsuhiko Noda
出版者
Tohoku University Medical Press
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.243, no.1, pp.35-39, 2017 (Released:2017-09-15)
参考文献数
13
被引用文献数
1

Carbohydrate-restricted diets are prevalent not only in obese people but also in the general population to maintain appropriate body weight. Here, we report that extreme carbohydrate restriction for one day affects the subsequent blood glucose levels in healthy adults. Ten subjects (median age 30.5 years, BMI 21.1 kg/m2, and HbA1c 5.5%), wearing with a continuous glucose monitoring device, were given isoenergetic test meals for 4 consecutive days. On day 1, day 2 (D2), and day 4 (D4), they consumed normal-carbohydrate (63-66% carbohydrate) diet, while on day 3, they took low-carbohydrate/high-fat (5% carbohydrate) diet. The daily energy intake was 2,200 kcal for males and 1,700 kcal for females. On D2 and D4, we calculated the mean 24-hr blood glucose level (MEAN/24h) and its standard deviation (SD/24h), the area under the curve (AUC) for glucose over 140 mg/dL within 4 hours after each meal (AUC/4h/140), the mean amplitude of the glycemic excursions (MAGE), the incremental AUC of 24-hr blood glucose level above the mean plus one standard deviation (iAUC/MEAN+SD). Indexes for glucose fluctuation on D4 were significantly greater than those on D2 (SD/24h; p = 0.009, MAGE; p = 0.013, AUC/4h/140 after breakfast and dinner; p = 0.006 and 0.005, and iAUC/MEAN+SD; p = 0.007). The value of MEAN/24h and AUC/4h/140 after lunch on D4 were greater than those on D2, but those differences were not statistically significant. In conclusion, consumption of low-carbohydrate/high-fat diet appears to cause higher postprandial blood glucose on subsequent normal-carbohydrate diet particularly after breakfast and dinner in healthy adults.

言及状況

外部データベース (DOI)

Twitter (5 users, 11 posts, 29 favorites)

@dramerling @JimJohnsonSci @drjasonfung A recent study recorded it with CGM after only one day of carb restriction https://t.co/XS07VQti3j
@IMWHorvitz @DoctorTro @KevinH_PhD @DrNadolsky @Drgarthdavis @davidludwigmd If OGTT is the objective, then yes, it’… https://t.co/KizgWDNPeH
@MacroFour @whsource Even healthy ‘non-diabetic’ subjects would fail, by that standard, after a single 24-period of… https://t.co/ei7B2LwKuw
@MHSJohnWright @raykellyfitness 2016 CGM athletic nonDM https://t.co/PfqyHpv5NG Snyder 2018… https://t.co/oEYtyiQH3J
@DrJonLittle @UBC_HES @ProfTimNoakes Nice, thankyou. Correlates with this 2017 study: “Postprandial Glucose Surg… https://t.co/8UTw1IyTUr
@Dr__Guess @JimJohnsonSci appreciate yr opinion on implications of this, for T2D lowcarb-remission criteria: D3=si… https://t.co/rCVnkB0KIT
@MacroFour After one day of 5% carb (D3, below), this healthy subject has entered ‘glucose sparing mode’ and on D4… https://t.co/kgpaALkvQm
Evidence that "cheat" days are not a good idea. Going from 5% carbs to a higher carb diet (63-66%) caused postpran… https://t.co/0Sy6RYA93u

収集済み URL リスト