著者
Nobuyoshi Ozawa Kiyoshi Ito Toru Tase Daisuke Shibuya Hirohito Metoki Nobuo Yaegashi
出版者
Tohoku University Medical Press
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.243, no.4, pp.329-334, 2017 (Released:2017-12-20)
参考文献数
13
被引用文献数
5

The Japanese national immunization programme for Human Papillomavirus (HPV) started in 2010. Vaccination rates increased up to 70% in women in the 1996-1999 birth. However, the proactive recommendation for HPV vaccine was suspended in 2013, following repeated media reports of adverse events. Vaccination rates plumped to less than 1% in women born since 2002. In this study, incidence of abnormal cytology and histology was examined in terms of HPV vaccination among 5,924 women aged 20 to 24 years in the fiscal year (FY) 2014 and 2015. The total rate of vaccination was 16.9% (1,002/5,924). In case of FY 2015, the rates of vaccination were 59.26%, 49.68%, 11.97%, 9.08%, and 4.58% in those aged 20, 21, 22, 23, and 24 years old, respectively. The rates of high-grade squamous intraepithelial lesion (HSIL) or worse were 0.20% (2/1,002) in women with HPV vaccination and 1.14% (56/4,922) in those without HPV vaccination, indicating a significant reduction of 82.46% with vaccination (P < 0.0001). The rates of cervical intraepithelial neoplasia (CIN) 1+ were 0.80% (8/1,002) in women with vaccination and 2.28% (112/4,922) in those without vaccination. The reduction rate of CIN1+ was 64.91% (P = 0.0025). The rates of CIN2+ were 0.10% (1/1,002) with vaccination and 0.69% (34/4,922) without vaccination. The reduction rate of CIN2+ was 85.51% (P = 0.0261). Our data are the first to demonstrate a significant reduction of CIN2+ cases in an Asian population. Scientific discussion is needed to restart the proactive recommendation for HPV vaccine in Japan.

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Lower Incidence of Cervical Intraepithelial Neoplasia among Young Women with Human Papillomavirus Vaccination in Miyagi, Japan 宮城県調査の続報。症例数を増やして前回に有意差がなかった子宮頸部高度病変の減少がHPVワクチン接種群でみられたアジア初の報告。 https://t.co/FVChzUTHXu
事実を積み重ねて!RT @EARL_Med_Tw: HPVワクチン(子宮頸がんワクチン)を接種した世代では子宮頚部上皮内腫瘍(cervical intraepitherial neoplasm: CIN)1+だけでなくCIN2+も85.5%有意に減少していた.宮城県5924例解析(Tohoku J Exp Med 2017;243:329-34) https://t.co/Oa0W37foDh
HPVワクチンによるCIN1+, CIN2+のreduction rateはそれぞれ64.9%, 85.5%という東北大の論文 CIN2+がワクチンありで0.10%,なしで0.69%。 https://t.co/DeoSFedN8r 割合と絶対値。数値をどう捉えるかは考え方。でも避けられ得るなら、自分は避けて欲しい。娘にも。 #HPVワクチン
"Lower Incidence of CIN among Young Women with HPV Vaccination in Miyagi, Japan": https://t.co/iq786SgDyv "The reduction rate of CIN1+ was 64.91% (P = 0.0025). ... The reduction rate of CIN2+ was 85.51% (P = 0.0261)."
HPVワクチン(子宮頸がんワクチン)を接種した世代では子宮頚部上皮内腫瘍(cervical intraepitherial neoplasm: CIN)1+だけでなくCIN2+も85.5%有意に減少していた.宮城県5924例解析(Tohoku J Exp Med 2017;243:329-34) 着実に有効性を示していきましょう https://t.co/zgpLNt5qdp

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