著者
佐藤 和之
出版者
公益社団法人 日本薬学会
雑誌
YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日
vol.126, no.8, pp.597-605, 2006-08-01 (Released:2006-08-01)
参考文献数
30
被引用文献数
2 2

Novel fluoroalkylated products where a CF2COOEt group was introduced at the α-position of α,β-unsaturated ketones or the Reformatsky-type products have been obtained selectively by the reaction of BrCF2COOEt and α,β-unsaturated ketones with Et2Zn in the presence of RhCl(PPh3)3 depending on the solvents. Furthermore, the novel α-fluoroalkylated products could synthesize by using various halofluoroalkyl compounds (Rf-X) instead of BrCF2COOEt. On the other hand, this Reformatsky-type reaction by imines gave difluoro-β-lactams or 3-amino-2,2-difluorocalboxylic esters without or with MgSO4•7H2O, selectively.

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