著者
堀江 俊治 田嶋 公人 松本 健次郎
出版者
公益社団法人 日本薬学会
雑誌
YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日
vol.138, no.8, pp.1003-1009, 2018-08-01 (Released:2018-08-01)
参考文献数
20

Capsaicin is a constituent of chili pepper, and induces the burning sensation on the tongue. The site of action for capsaicin has been discovered as transient receptor potential vanilloid receptor subtype 1 (TRPV1) that resides on the membranes of pain- and heat-sensing primary afferent nerves. The immunohistochemical study on the stomach revealed that nerve fibers expressing TRPV1 exist along gastric glands in the mucosa, around blood vessels in the submucosa, in the myenteric plexus, and in the smooth muscle layers. High numbers of TRPV1-immunoreactive axons were observed in the rectum and distal colon. Therefore, capsaicin stimulates TRPV1 not only on the tongue but also in the gut. In this review, the mechanism of gastrointestinal mucosal defense enhanced by capsaicin was summarized. TRPV1 plays a protective role in gastrointestinal mucosal defensive mechanism. Hypersensitivity of afferent fibers occurs during gastrointestinal inflammation. Abnormalities of primary afferent nerve fibers are strongly associated with the visceral hypersensitive state in inflammatory bowel disease (IBD). The alteration of TRPV1 channels in mucosa contributes to the visceral hypersensitivity in colitis model mice. TRPV1-expressing neurons in the gut are thought to be extrinsic sensory afferent neurons that operate to maintain gastrointestinal functions under physiological and inflammatory states.

言及状況

外部データベース (DOI)

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大腸、肛門側の方がカプサイシンに反応しやすいって致命的な欠陥すぎるだろ https://t.co/HpIiEO8k0m https://t.co/ILV923UH0l
消化管スパイスセンサー?? な~んじゃそれっ
@nagy79n 詳しくはこちらの論文で。 炎症が起こってると、カプサイシンの受容体が増えて、カプサイシンの影響を受けやすくなり、結果的に下痢する、というワケですな。 …過敏性腸症候群なんだろうか…?? https://t.co/ug3MEOVK7y
カプサイシンが作用する機序はここに載ってました。この辺が違うのかも知れません。 https://t.co/Bf6Xt0TOSE https://t.co/ZagUnQJyNl

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