著者
三島 健一 入江 圭一
出版者
公益社団法人 日本薬学会
雑誌
YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日
vol.140, no.2, pp.193-204, 2020-02-01 (Released:2020-02-01)
参考文献数
36
被引用文献数
1 1

Cannabis contains over 700 known cannabinoids, terpenoids, flavonoids, and so on; however, the roles and importance of these components have yet to be fully understood. Δ9-Tetrahydrocannabinol (THC) is believed the most psychoactive component in cannabis, whereas cannabidiol (CBD), cannabinol, and cannabigerol are the most well-known non-psychoactive components. THC, but not CBD, has been shown to produce abnormal behavior in animals; these effects are caused, at least in part, by binding to cannabinoid receptor type 1 (CB1) in the brain. Regarding the risks associated with cannabis use, acute effects of THC, such as a “high”, cognitive deficits, and irritability, are considered more important than potential dependence. On the other hand, CBD has shown anticonvulsant, anti-inflammatory, immunosuppressive, analgesic, and anticancer effects. However, CBD has very low affinity (in the micromolar range) for the CB1 receptor, as well as for the CB2 receptor, and its underlying mechanism remains obscure. In this review, we demonstrate that THC induces abnormal behavior such as catalepsy-like immobilization, spatial memory impairment, and high and low sensitivity to ultrasonic vocalization after an aversive air-puff stimulus. Moreover, we demonstrate that THC and CBD improve brain injury in middle cerebral artery occlusion in a mouse model through different mechanisms. These findings suggest the need to discuss the recent development of “THC and CBD pharmacology” in animal studies, as well as the utility and risk of various cannabis components in humans.

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@bristlecorkscr1 初めまして。今の所、 N-arachidonoylethanolamide、(anandamide; AEA), 2-arachidonoyl glycerol (2-AG), 2-arachidonoyl glycerol ether, oleamide など脂質分 子。 です。 引用文献:大麻成分の中枢効果 有用性と危険性https://t.co/Iy6zZogwkP
大麻成分の健康影響は「分かっていない点が多い」から誰も語ることができない。 私は岩永先生が知っていて言わなかったか、報道誌自身が理解できないか、論点ずらしのために削ったとしか思えません。 文献↓ 大麻成分の中枢効果 有用性と危険性:https://t.co/Iy6zZogwkP https://t.co/G9FuhWWJLc
https://t.co/ibXuN0m1h0 大麻成分の中枢効果:有用性と危険性 三島 健一, 入江 圭一
大麻成分の中枢効果有用性と危険性 (2020年の物の様で現段階のTHCとCBDについて分かっている事を詳しく知ることが出来そうです) https://t.co/dquzwtx5hA

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