著者
中村 斐有 安井 孝介 Phil S. Baran
出版者
公益社団法人 有機合成化学協会
雑誌
有機合成化学協会誌 (ISSN:00379980)
巻号頁・発行日
vol.79, no.4, pp.333-343, 2021-04-01 (Released:2021-04-07)
参考文献数
32

Teleocidine B family was isolated in1960 by Sakai group and was shown to have highly potent protein kinase-C (PKC) activation, similar to that of phorbol and related natural products. In this report, we have developed a unified total synthesis of teleocidins B-1-B-4 in 11 chemical steps. The highlights of the work are 1) the Ni catalyzed electrochemical amination, 2) Cu-mediated aziridine opening followed by direct macrolactamization, and 3) the tactical combination of C-H borylation and a redox-relay chain walking (RRCW) methodology to make the carbon quaternary center.

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#DELFinder Total synthesis of Teleocidin B by Redox-Relay Chain Walking https://t.co/iKnKRlq7XZ #DELopen https://t.co/U1BUF63FxE

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